Selective inhibition of neuronal nitric oxide synthase fails to alter the resting tension and the relaxant effect of bradykinin in isolated rat middle cerebral arteries

Zoltán Benyó, Z. Lacza, Ch Görlach, M. Wahl

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The role of the neuronal isoform of the nitric oxide (NO) synthase (nNOS) in the regulation of the cerebrovascular tone was studied in vitro. Selective inhibition of nNOS by 7-nitro indazole monosodium salt (7-NINA) failed to alter the resting tension and the relaxant effect of bradykinin in isolated rat middle cerebral arteries. These results indicate that 1./ 7-NINA is selective for nNOS and 2./ cerebrovascular nNOS is involved neither in the resting NO production nor in the mediation of the relaxant effect of bradykinin. Therefore, nNOS-derived NO that contributes to the maintenance of the resting cerebral blood flow in vivo appears to be released from neurons and/or glial cells.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalActa Physiologica Hungarica
Volume86
Issue number2
Publication statusPublished - 1999

Fingerprint

Nitric Oxide Synthase Type I
Middle Cerebral Artery
Bradykinin
Cerebrovascular Circulation
Nitric Oxide
Salts
Neuroglia
Protein Isoforms
Maintenance
Neurons
7-nitroindazole
In Vitro Techniques

Keywords

  • 7-nitro indazole monosodium salt
  • Bradykinin
  • Endothelium
  • Neuronal nitric oxide synthase
  • Rat middle cerebral artery

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "The role of the neuronal isoform of the nitric oxide (NO) synthase (nNOS) in the regulation of the cerebrovascular tone was studied in vitro. Selective inhibition of nNOS by 7-nitro indazole monosodium salt (7-NINA) failed to alter the resting tension and the relaxant effect of bradykinin in isolated rat middle cerebral arteries. These results indicate that 1./ 7-NINA is selective for nNOS and 2./ cerebrovascular nNOS is involved neither in the resting NO production nor in the mediation of the relaxant effect of bradykinin. Therefore, nNOS-derived NO that contributes to the maintenance of the resting cerebral blood flow in vivo appears to be released from neurons and/or glial cells.",
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AU - Benyó, Zoltán

AU - Lacza, Z.

AU - Görlach, Ch

AU - Wahl, M.

PY - 1999

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AB - The role of the neuronal isoform of the nitric oxide (NO) synthase (nNOS) in the regulation of the cerebrovascular tone was studied in vitro. Selective inhibition of nNOS by 7-nitro indazole monosodium salt (7-NINA) failed to alter the resting tension and the relaxant effect of bradykinin in isolated rat middle cerebral arteries. These results indicate that 1./ 7-NINA is selective for nNOS and 2./ cerebrovascular nNOS is involved neither in the resting NO production nor in the mediation of the relaxant effect of bradykinin. Therefore, nNOS-derived NO that contributes to the maintenance of the resting cerebral blood flow in vivo appears to be released from neurons and/or glial cells.

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