Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Judit K. Makara, Marco Mor, Darren Fegley, Szilárd I. Szabó, Satish Kathuria, Giuseppe Astarita, Andrea Duranti, Andrea Tontini, Giorgio Tarzia, Silvia Rivara, Tamás F. Freund, Daniele Piomelli

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.

Original languageEnglish
Pages (from-to)1139-1141
Number of pages3
JournalNature Neuroscience
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 1 2005

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Makara, J. K., Mor, M., Fegley, D., Szabó, S. I., Kathuria, S., Astarita, G., Duranti, A., Tontini, A., Tarzia, G., Rivara, S., Freund, T. F., & Piomelli, D. (2005). Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nature Neuroscience, 8(9), 1139-1141. https://doi.org/10.1038/nn1521