Selective GABAergic control of higher-order thalamic relays

Hajnalka Bokor, Samuel G A Frère, Mark D. Eyre, Andrea Slézia, I. Ulbert, Anita Lüthi, L. Acsády

Research output: Contribution to journalArticle

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Abstract

GABAergic signaling is central to the function of the thalamus and has been traditionally attributed primarily to the nucleus reticularis thalami (nRT). Here we present a GABAergic pathway, distinct from the nRT, that exerts a powerful inhibitory effect selectively in higher-order thalamic relays of the rat. Axons originating in the anterior pretectal nucleus (APT) innervated the proximal dendrites of relay cells via large GABAergic terminals with multiple release sites. Stimulation of the APT in an in vitro slice preparation revealed a GABAA receptor-mediated, monosynaptic IPSC in relay cells. Activation of presumed single APT fibers induced rebound burst firing in relay cells. Different APT neurons recorded in vivo displayed fast bursting, tonic, or rhythmic firing. Our data suggest that selective extrareticular GABAergic control of relay cell activity will result in effective, state-dependent gating of thalamocortical information transfer in higher-order but not in first-order relays.

Original languageEnglish
Pages (from-to)929-940
Number of pages12
JournalNeuron
Volume45
Issue number6
DOIs
Publication statusPublished - Mar 24 2005

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Thalamus
GABA-A Receptors
Dendrites
Axons
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bokor, H., Frère, S. G. A., Eyre, M. D., Slézia, A., Ulbert, I., Lüthi, A., & Acsády, L. (2005). Selective GABAergic control of higher-order thalamic relays. Neuron, 45(6), 929-940. https://doi.org/10.1016/j.neuron.2005.01.048

Selective GABAergic control of higher-order thalamic relays. / Bokor, Hajnalka; Frère, Samuel G A; Eyre, Mark D.; Slézia, Andrea; Ulbert, I.; Lüthi, Anita; Acsády, L.

In: Neuron, Vol. 45, No. 6, 24.03.2005, p. 929-940.

Research output: Contribution to journalArticle

Bokor, H, Frère, SGA, Eyre, MD, Slézia, A, Ulbert, I, Lüthi, A & Acsády, L 2005, 'Selective GABAergic control of higher-order thalamic relays', Neuron, vol. 45, no. 6, pp. 929-940. https://doi.org/10.1016/j.neuron.2005.01.048
Bokor H, Frère SGA, Eyre MD, Slézia A, Ulbert I, Lüthi A et al. Selective GABAergic control of higher-order thalamic relays. Neuron. 2005 Mar 24;45(6):929-940. https://doi.org/10.1016/j.neuron.2005.01.048
Bokor, Hajnalka ; Frère, Samuel G A ; Eyre, Mark D. ; Slézia, Andrea ; Ulbert, I. ; Lüthi, Anita ; Acsády, L. / Selective GABAergic control of higher-order thalamic relays. In: Neuron. 2005 ; Vol. 45, No. 6. pp. 929-940.
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