Selective depletion of somatostatin in rat brain by cysteamine

M. Palkóvits, M. J. Brownstein, L. E. Eiden, M. C. Beinfeld, J. Russell, A. Arimura, S. Szabo

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

A single injection of cysteamine (300 mg/kg, subcutaneously) results in a 70-80% decrease in somatostatin levels in the periventricular nucleus where somatostatin-producing neurons are located and the median eminence where somatostatinergic nerve terminals are. The drug seems quite selective: no changes in levels of other neuropeptides - LH-RH, vasopressin, enkephalin, VIP, CCK - were observed in the same animals.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalBrain Research
Volume240
Issue number1
DOIs
Publication statusPublished - May 20 1982

Fingerprint

Cysteamine
Somatostatin
Median Eminence
Enkephalins
Brain
Neuropeptides
Vasopressins
Gonadotropin-Releasing Hormone
Neurons
Injections
Pharmaceutical Preparations

Keywords

  • brain nuclei
  • cysteamine
  • neuropeptide
  • somatostatin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Palkóvits, M., Brownstein, M. J., Eiden, L. E., Beinfeld, M. C., Russell, J., Arimura, A., & Szabo, S. (1982). Selective depletion of somatostatin in rat brain by cysteamine. Brain Research, 240(1), 178-180. https://doi.org/10.1016/0006-8993(82)90660-6

Selective depletion of somatostatin in rat brain by cysteamine. / Palkóvits, M.; Brownstein, M. J.; Eiden, L. E.; Beinfeld, M. C.; Russell, J.; Arimura, A.; Szabo, S.

In: Brain Research, Vol. 240, No. 1, 20.05.1982, p. 178-180.

Research output: Contribution to journalArticle

Palkóvits, M, Brownstein, MJ, Eiden, LE, Beinfeld, MC, Russell, J, Arimura, A & Szabo, S 1982, 'Selective depletion of somatostatin in rat brain by cysteamine', Brain Research, vol. 240, no. 1, pp. 178-180. https://doi.org/10.1016/0006-8993(82)90660-6
Palkóvits M, Brownstein MJ, Eiden LE, Beinfeld MC, Russell J, Arimura A et al. Selective depletion of somatostatin in rat brain by cysteamine. Brain Research. 1982 May 20;240(1):178-180. https://doi.org/10.1016/0006-8993(82)90660-6
Palkóvits, M. ; Brownstein, M. J. ; Eiden, L. E. ; Beinfeld, M. C. ; Russell, J. ; Arimura, A. ; Szabo, S. / Selective depletion of somatostatin in rat brain by cysteamine. In: Brain Research. 1982 ; Vol. 240, No. 1. pp. 178-180.
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