Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat

G. Jancso, Elizabeth Király, F. Joó, G. Such, Anikó Nagy

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

The morphological effects of systemic capsaicin treatment have been studied in adult rats. Light and electron microscopy revealed that a subpopulation of small-to-medium sized B-type primary sensory neurons, representing about 17% of the total neuronal population in the 4th lumbar spinal ganglion, underwent rapid degeneration after the administration of capsaicin. Quantitative electron microscopy demonstrated a decrease of about 45% in the number of unmyelinated axons in the saphenous nerve. Light microscopy showed extensive axon terminal degeneration in the brainstem and spinal cord confined to the central projection areas of capsaicin-sensitive afferent fibers, as has already been revealed in the newborn rat. The present results furnish evidence for a hitherto unrecognized selective neurodegenerative action of capsaicin in the adult rat.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalNeuroscience Letters
Volume59
Issue number2
DOIs
Publication statusPublished - Aug 30 1985

Keywords

  • adult rat
  • capsaicin
  • degeneration
  • primary sensory neuron

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat'. Together they form a unique fingerprint.

  • Cite this