Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat

G. Jancsó, Elizabeth Király, F. Joó, G. Such, Anikó Nagy

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Abstract

The morphological effects of systemic capsaicin treatment have been studied in adult rats. Light and electron microscopy revealed that a subpopulation of small-to-medium sized B-type primary sensory neurons, representing about 17% of the total neuronal population in the 4th lumbar spinal ganglion, underwent rapid degeneration after the administration of capsaicin. Quantitative electron microscopy demonstrated a decrease of about 45% in the number of unmyelinated axons in the saphenous nerve. Light microscopy showed extensive axon terminal degeneration in the brainstem and spinal cord confined to the central projection areas of capsaicin-sensitive afferent fibers, as has already been revealed in the newborn rat. The present results furnish evidence for a hitherto unrecognized selective neurodegenerative action of capsaicin in the adult rat.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalNeuroscience Letters
Volume59
Issue number2
DOIs
Publication statusPublished - 1985

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Capsaicin
Sensory Receptor Cells
Electron Microscopy
Light
Presynaptic Terminals
Spinal Ganglia
Brain Stem
Axons
Microscopy
Spinal Cord
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat. / Jancsó, G.; Király, Elizabeth; Joó, F.; Such, G.; Nagy, Anikó.

In: Neuroscience Letters, Vol. 59, No. 2, 1985, p. 209-214.

Research output: Contribution to journalArticle

Jancsó, G. ; Király, Elizabeth ; Joó, F. ; Such, G. ; Nagy, Anikó. / Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat. In: Neuroscience Letters. 1985 ; Vol. 59, No. 2. pp. 209-214.
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