In dose studies, cysteamine pretreatment in a dose of 200 mg/kg or 300 mg/kg (subcuteneously, s.c.) markedly decreased the hypothalamic noradrenaline content, but did not influence the dopamine and serotonin contents. In time studies, pretreatment with cysteamine in a dose of 300 mg/kg (s.c.) led to markedly decreased hypothalamic noradrenaline contents 4 hr, 8 hr and 12 hr after treatment. These results suggest that cysteamine treatment selectively decreases the hypothalamic noradrenaline content in dose- and time-related manners.
|Number of pages||4|
|Journal||Archives internationales de pharmacodynamie et de therapie|
|Publication status||Published - Jan 1 1985|
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