Selective decrease of hypothalamic noradrenaline by cysteamine

L. Vecsei, M. Balazs, I. Bollok, G. Telegdy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In dose studies, cysteamine pretreatment in a dose of 200 mg/kg or 300 mg/kg (subcuteneously, s.c.) markedly decreased the hypothalamic noradrenaline content, but did not influence the dopamine and serotonin contents. In time studies, pretreatment with cysteamine in a dose of 300 mg/kg (s.c.) led to markedly decreased hypothalamic noradrenaline contents 4 hr, 8 hr and 12 hr after treatment. These results suggest that cysteamine treatment selectively decreases the hypothalamic noradrenaline content in dose- and time-related manners.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalArchives internationales de pharmacodynamie et de therapie
Volume274
Issue number1
Publication statusPublished - Jan 1 1985

ASJC Scopus subject areas

  • Pharmacology

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