Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA

András Földesi, Anna Trifonova, Zoltán Dinya, Jyoti Chattopadhyaya

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3 Citations (Scopus)


A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N2-(Ac or iBu)-O6-DPC-guanosine to N2-(Ac or iBu)-guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC group followed by treatment with sodium ethoxide in pyridine-ethanol mixture at room temperature.

Original languageEnglish
Pages (from-to)7283-7284
Number of pages2
JournalTetrahedron Letters
Issue number40
Publication statusPublished - Oct 1 1999


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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