Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA

András Földesi, Anna Trifonova, Z. Dinya, Jyoti Chattopadhyaya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N2-(Ac or iBu)-O6-DPC-guanosine to N2-(Ac or iBu)-guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC group followed by treatment with sodium ethoxide in pyridine-ethanol mixture at room temperature.

Original languageEnglish
Pages (from-to)7283-7284
Number of pages2
JournalTetrahedron Letters
Volume40
Issue number40
DOIs
Publication statusPublished - Oct 1 1999

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Guanosine
Sugars
RNA
Ethanol
Temperature
pyridine
sodium ethoxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA. / Földesi, András; Trifonova, Anna; Dinya, Z.; Chattopadhyaya, Jyoti.

In: Tetrahedron Letters, Vol. 40, No. 40, 01.10.1999, p. 7283-7284.

Research output: Contribution to journalArticle

Földesi, András ; Trifonova, Anna ; Dinya, Z. ; Chattopadhyaya, Jyoti. / Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 40. pp. 7283-7284.
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