Selective attenuation of passive avoidance behaviour by microinjection of β-LPH62-77 and β-LPH66-77 into the nucleus accumbens in rats

G. Kovács, G. Telegdy, D. De Wied

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Various fragments of β-lipotropin were micro-injected into the nucleus accumbens of freemoving rats and the effects on one-trial passive avoidance behaviour were studied. The following peptides were used: β-endorphin (β-LPH61-91, met-enkephalin(β-LPH61-65) des-tyrosine-γ-endorphin (DTγE, β-LPH62-77), des-enkephalin-γ-endorphin (DEγE, β-LPH66-77), des-tyrosine-α-endorphin (DTαE, β-LPH62-76) and β-LPH47-53(ACTH4-10). The γ-type endorphins (DTγE and DEγE) were the only peptides which significantly attenuated passive avoidance behaviour when given in a 20 pg dose 1 hr before the 24-hr retention test. All the other peptides were ineffective. Microinjection of DTγE into the dentate gyrus of the dorsal hippocampus, on the other hand, was without effect on passive avoidance. The accumbens nucleus, therefore, is a preferential highly sensitive brain site for γ-type endorphins. The attenuation of passive avoidance behaviour following systemic administration of these peptides might be the result of an interaction with this mesolimbic structure.

Original languageEnglish
Pages (from-to)451-454
Number of pages4
JournalNeuropharmacology
Volume21
Issue number5
DOIs
Publication statusPublished - 1982

Fingerprint

Avoidance Learning
Endorphins
Nucleus Accumbens
Microinjections
Peptides
Tyrosine
beta-Lipotropin
Parahippocampal Gyrus
Methionine Enkephalin
Enkephalins
Dentate Gyrus
Brain

Keywords

  • DEγE
  • DTγE
  • nucleus accumbens
  • passive avoidance

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

@article{44fac23981c448549bbe5768f840751d,
title = "Selective attenuation of passive avoidance behaviour by microinjection of β-LPH62-77 and β-LPH66-77 into the nucleus accumbens in rats",
abstract = "Various fragments of β-lipotropin were micro-injected into the nucleus accumbens of freemoving rats and the effects on one-trial passive avoidance behaviour were studied. The following peptides were used: β-endorphin (β-LPH61-91, met-enkephalin(β-LPH61-65) des-tyrosine-γ-endorphin (DTγE, β-LPH62-77), des-enkephalin-γ-endorphin (DEγE, β-LPH66-77), des-tyrosine-α-endorphin (DTαE, β-LPH62-76) and β-LPH47-53(ACTH4-10). The γ-type endorphins (DTγE and DEγE) were the only peptides which significantly attenuated passive avoidance behaviour when given in a 20 pg dose 1 hr before the 24-hr retention test. All the other peptides were ineffective. Microinjection of DTγE into the dentate gyrus of the dorsal hippocampus, on the other hand, was without effect on passive avoidance. The accumbens nucleus, therefore, is a preferential highly sensitive brain site for γ-type endorphins. The attenuation of passive avoidance behaviour following systemic administration of these peptides might be the result of an interaction with this mesolimbic structure.",
keywords = "DEγE, DTγE, nucleus accumbens, passive avoidance",
author = "G. Kov{\'a}cs and G. Telegdy and {De Wied}, D.",
year = "1982",
doi = "10.1016/0028-3908(82)90030-2",
language = "English",
volume = "21",
pages = "451--454",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Selective attenuation of passive avoidance behaviour by microinjection of β-LPH62-77 and β-LPH66-77 into the nucleus accumbens in rats

AU - Kovács, G.

AU - Telegdy, G.

AU - De Wied, D.

PY - 1982

Y1 - 1982

N2 - Various fragments of β-lipotropin were micro-injected into the nucleus accumbens of freemoving rats and the effects on one-trial passive avoidance behaviour were studied. The following peptides were used: β-endorphin (β-LPH61-91, met-enkephalin(β-LPH61-65) des-tyrosine-γ-endorphin (DTγE, β-LPH62-77), des-enkephalin-γ-endorphin (DEγE, β-LPH66-77), des-tyrosine-α-endorphin (DTαE, β-LPH62-76) and β-LPH47-53(ACTH4-10). The γ-type endorphins (DTγE and DEγE) were the only peptides which significantly attenuated passive avoidance behaviour when given in a 20 pg dose 1 hr before the 24-hr retention test. All the other peptides were ineffective. Microinjection of DTγE into the dentate gyrus of the dorsal hippocampus, on the other hand, was without effect on passive avoidance. The accumbens nucleus, therefore, is a preferential highly sensitive brain site for γ-type endorphins. The attenuation of passive avoidance behaviour following systemic administration of these peptides might be the result of an interaction with this mesolimbic structure.

AB - Various fragments of β-lipotropin were micro-injected into the nucleus accumbens of freemoving rats and the effects on one-trial passive avoidance behaviour were studied. The following peptides were used: β-endorphin (β-LPH61-91, met-enkephalin(β-LPH61-65) des-tyrosine-γ-endorphin (DTγE, β-LPH62-77), des-enkephalin-γ-endorphin (DEγE, β-LPH66-77), des-tyrosine-α-endorphin (DTαE, β-LPH62-76) and β-LPH47-53(ACTH4-10). The γ-type endorphins (DTγE and DEγE) were the only peptides which significantly attenuated passive avoidance behaviour when given in a 20 pg dose 1 hr before the 24-hr retention test. All the other peptides were ineffective. Microinjection of DTγE into the dentate gyrus of the dorsal hippocampus, on the other hand, was without effect on passive avoidance. The accumbens nucleus, therefore, is a preferential highly sensitive brain site for γ-type endorphins. The attenuation of passive avoidance behaviour following systemic administration of these peptides might be the result of an interaction with this mesolimbic structure.

KW - DEγE

KW - DTγE

KW - nucleus accumbens

KW - passive avoidance

UR - http://www.scopus.com/inward/record.url?scp=0020030131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020030131&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(82)90030-2

DO - 10.1016/0028-3908(82)90030-2

M3 - Article

C2 - 7110535

AN - SCOPUS:0020030131

VL - 21

SP - 451

EP - 454

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 5

ER -