Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy

Marton Graf, Rita Jakus, Sandor Kantor, Gyorgy Levay, Gyorgy Bagdy

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume359
Issue number1-2
DOIs
Publication statusPublished - Apr 8 2004

Keywords

  • 5-HT receptor
  • 5-HT receptor
  • Absence epilepsy
  • Animal model
  • Spike-wave discharges
  • WAG/Rij rat

ASJC Scopus subject areas

  • Neuroscience(all)

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