Selection of solubility parameters for characterization of pharmaceutical excipients

Katarzyna Adamska, Adam Voelkel, Károly Héberger

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The solubility parameter (δ2), corrected solubility parameter (δT) and its components (δd, δp, δh) were determined for series of pharmaceutical excipients by using inverse gas chromatography (IGC). Principal component analysis (PCA) was applied for the selection of the solubility parameters which assure the complete characterization of examined materials. Application of PCA suggests that complete description of examined materials is achieved with four solubility parameters, i.e. δ2 and Hansen solubility parameters (δd, δp, δh). Selection of the excipients through PCA of their solubility parameters data can be used for prediction of their behavior in a multi-component system, e.g. for selection of the best materials to form stable pharmaceutical liquid mixtures or stable coating formulation.

Original languageEnglish
Pages (from-to)90-97
Number of pages8
JournalJournal of Chromatography A
Issue number1-2
Publication statusPublished - Nov 9 2007



  • Chemometrics
  • Hansen solubility parameters
  • Inverse gas chromatography
  • Principal component analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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