Selection of lon mutants in Escherichia coli by treatment with phenothiazines

J. Molnár, I. B. Holland, Yvette Mándi

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Growth of E. coli K12 in the presence of chlorpromazine or promethazine resulted in the appearance of a special kind of mutational change with a frequency of 5–10%. These cells were UV-sensitive and very mucoid in their colony formation. The strains were characterized as colanic acid producing on the basis of phage m-59 sensitivity and we tentatively conclude that these mutants are Lon. In another series of experiments drug treatment of E. coli failed to yield significant numbers of auxotrophs and the back mutation rate of a number of S. typhimurium His strains was not significantly increased.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalGenetical Research
Issue number1
Publication statusPublished - Aug 1977


ASJC Scopus subject areas

  • Genetics

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