Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

Veijo T. Salo, Shiqian Li, Helena Vihinen, Maarit Hölttä-Vuori, Abel Szkalisity, P. Horváth, Ilya Belevich, Johan Peränen, Christoph Thiele, Pentti Somerharju, Hongxia Zhao, Alexandre Santinho, Abdou Rachid Thiam, Eija Jokitalo, Elina Ikonen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Salo et al. show that seipin determines where a lipid droplet (LD) forms and establishes a neck between ER and LD. LDs continuously exchange lipids via ER, and biophysically, larger LDs acquire lipids more readily than smaller ones. Seipin facilitates lipid transfer to droplets, helping small LDs to grow.

Original languageEnglish
Pages (from-to)478-493.e9
JournalDevelopmental Cell
Volume50
Issue number4
DOIs
Publication statusPublished - Aug 19 2019

Fingerprint

Endoplasmic Reticulum
Contacts (fluid mechanics)
Triglycerides
Lipids
Neck
Lipid Droplets

Keywords

  • auxin-induced degradation
  • correlative light electron microscopy
  • electron tomography
  • lipid trafficking
  • lipogenesis
  • membrane contacts
  • model membranes
  • neutral lipid
  • organelle biogenesis
  • triglyceride

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. / Salo, Veijo T.; Li, Shiqian; Vihinen, Helena; Hölttä-Vuori, Maarit; Szkalisity, Abel; Horváth, P.; Belevich, Ilya; Peränen, Johan; Thiele, Christoph; Somerharju, Pentti; Zhao, Hongxia; Santinho, Alexandre; Thiam, Abdou Rachid; Jokitalo, Eija; Ikonen, Elina.

In: Developmental Cell, Vol. 50, No. 4, 19.08.2019, p. 478-493.e9.

Research output: Contribution to journalArticle

Salo, VT, Li, S, Vihinen, H, Hölttä-Vuori, M, Szkalisity, A, Horváth, P, Belevich, I, Peränen, J, Thiele, C, Somerharju, P, Zhao, H, Santinho, A, Thiam, AR, Jokitalo, E & Ikonen, E 2019, 'Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact', Developmental Cell, vol. 50, no. 4, pp. 478-493.e9. https://doi.org/10.1016/j.devcel.2019.05.016
Salo, Veijo T. ; Li, Shiqian ; Vihinen, Helena ; Hölttä-Vuori, Maarit ; Szkalisity, Abel ; Horváth, P. ; Belevich, Ilya ; Peränen, Johan ; Thiele, Christoph ; Somerharju, Pentti ; Zhao, Hongxia ; Santinho, Alexandre ; Thiam, Abdou Rachid ; Jokitalo, Eija ; Ikonen, Elina. / Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. In: Developmental Cell. 2019 ; Vol. 50, No. 4. pp. 478-493.e9.
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