Segmental differences in geometric, elastic and contractile characteristics of small intramural coronary arteries of the rat

Mária Szekeres, G. Nádasy, László Dézsi, Miklós Orosz, A. Tőkés, E. Monos

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The dependence of elastic and contractile properties on the caliber of small intramural coronary arteries was investigated in the rat in vitro. Different segments of the left anterior descending coronary artery branching system were prepared for microarteriography. The segments were cannulated at both ends, immersed in oxygenated normal Krebs Ringer (nKR) solution. Intraluminal pressure was changed at a rate of about 0.5 mm Hg/s between 0 and 150 mm Hg in repeated cycles. The outer diameter was continuously measured with microangiometry. Pressure-diameter curves were recorded after preconditioning pressure cycles in nKR, with PGF(2α) in the bath (7.5 x 10- 6 M), and in maximal relaxation with papaverine (2.8 x 10-4 M). Biomechanical parameters were computed for vessels grouped according to their calibers (inner diameters: 50-150, 150-250, 250-350,>350 μm). Distensibility and contractility decreased with increasing caliber of the vessels, while the elastic modulus increased. Spontaneous tone was (at 100 mm Hg in mechanically preconditioned vessels) 18.8 ± 4.5, 8.4 ± 4.4, 9.7 ± 3.7 and 8.3 ± 3.8% in the four groups, respectively. PGF(2α) contraction was maximal around the 300-μm caliber. Our study is the first direct demonstration that intramural small coronary arteries exhibit characteristic variability in their elastic and contractile properties as a function of their caliber. Such differences may be important in segmentally specific control processes of the coronary microcirculation.

Original languageEnglish
Pages (from-to)332-344
Number of pages13
JournalJournal of Vascular Research
Volume35
Issue number5
DOIs
Publication statusPublished - Sep 1998

Fingerprint

Coronary Vessels
Prostaglandins F
Pressure
Papaverine
Elastic Modulus
Microcirculation
Baths
Krebs-Ringer solution
In Vitro Techniques

Keywords

  • Coronary arteries, small
  • Elasticity, coronary arteries
  • Intramural coronary vessels
  • Isolated vessel
  • PGF(2α)
  • Vascular biomechanics
  • Vascular tone

ASJC Scopus subject areas

  • Physiology

Cite this

Segmental differences in geometric, elastic and contractile characteristics of small intramural coronary arteries of the rat. / Szekeres, Mária; Nádasy, G.; Dézsi, László; Orosz, Miklós; Tőkés, A.; Monos, E.

In: Journal of Vascular Research, Vol. 35, No. 5, 09.1998, p. 332-344.

Research output: Contribution to journalArticle

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