Secretion and breakdown of insulin in hyperthyroidism

J. Foldes, C. Banos, A. Varadi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a study of the disorders of glucose metabolism associated with hyperthyroidism 16 euthyroid subjects and 19 patients with untreated hyperthyroidism, age ranging between 20 and 50 years, were subjected to an oral glucose tolerance test with 100 g glucose. The serum thyroxine, triiodothyronine, reverse triiodothyronine, and TSH concentrations remained unchanged. This ruled out the possibility that modifications of thyroid hormone secretion or of thyroid hormone metabolism in response to acute glucose loading might affect the secretion of insulin and C peptide. It has been confirmed by the results that the insulin response to oral glucose loading, in proportion to the increase in blood glucose concentration, is weaker in hyperthyroid than in euthyroid subjects, At the same time, extraction of insulin in the liver is slightly increased in thyrotoxicosis. All this may contribute to the impaired glucose tolerance associated with hyperthyroidism. The results also indicate that the insulin response to oral glucose loading in hyperthyroidism remains unaffected by the administration of beta-blocking agents.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalActa Medica Academiae Scientiarum Hungaricae
Volume38
Issue number3
Publication statusPublished - 1981

Fingerprint

Hyperthyroidism
Insulin
Glucose
Thyroid Hormones
Glucose Metabolism Disorders
Reverse Triiodothyronine
Thyrotoxicosis
Glucose Intolerance
C-Peptide
Triiodothyronine
Glucose Tolerance Test
Thyroxine
Blood Glucose
Liver
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Secretion and breakdown of insulin in hyperthyroidism. / Foldes, J.; Banos, C.; Varadi, A.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 38, No. 3, 1981, p. 197-205.

Research output: Contribution to journalArticle

@article{090ff70138de4074bb0f100c5d4cd34e,
title = "Secretion and breakdown of insulin in hyperthyroidism",
abstract = "In a study of the disorders of glucose metabolism associated with hyperthyroidism 16 euthyroid subjects and 19 patients with untreated hyperthyroidism, age ranging between 20 and 50 years, were subjected to an oral glucose tolerance test with 100 g glucose. The serum thyroxine, triiodothyronine, reverse triiodothyronine, and TSH concentrations remained unchanged. This ruled out the possibility that modifications of thyroid hormone secretion or of thyroid hormone metabolism in response to acute glucose loading might affect the secretion of insulin and C peptide. It has been confirmed by the results that the insulin response to oral glucose loading, in proportion to the increase in blood glucose concentration, is weaker in hyperthyroid than in euthyroid subjects, At the same time, extraction of insulin in the liver is slightly increased in thyrotoxicosis. All this may contribute to the impaired glucose tolerance associated with hyperthyroidism. The results also indicate that the insulin response to oral glucose loading in hyperthyroidism remains unaffected by the administration of beta-blocking agents.",
author = "J. Foldes and C. Banos and A. Varadi",
year = "1981",
language = "English",
volume = "38",
pages = "197--205",
journal = "Acta Medica Academiae Scientiarum Hungaricae",
issn = "0001-5989",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - Secretion and breakdown of insulin in hyperthyroidism

AU - Foldes, J.

AU - Banos, C.

AU - Varadi, A.

PY - 1981

Y1 - 1981

N2 - In a study of the disorders of glucose metabolism associated with hyperthyroidism 16 euthyroid subjects and 19 patients with untreated hyperthyroidism, age ranging between 20 and 50 years, were subjected to an oral glucose tolerance test with 100 g glucose. The serum thyroxine, triiodothyronine, reverse triiodothyronine, and TSH concentrations remained unchanged. This ruled out the possibility that modifications of thyroid hormone secretion or of thyroid hormone metabolism in response to acute glucose loading might affect the secretion of insulin and C peptide. It has been confirmed by the results that the insulin response to oral glucose loading, in proportion to the increase in blood glucose concentration, is weaker in hyperthyroid than in euthyroid subjects, At the same time, extraction of insulin in the liver is slightly increased in thyrotoxicosis. All this may contribute to the impaired glucose tolerance associated with hyperthyroidism. The results also indicate that the insulin response to oral glucose loading in hyperthyroidism remains unaffected by the administration of beta-blocking agents.

AB - In a study of the disorders of glucose metabolism associated with hyperthyroidism 16 euthyroid subjects and 19 patients with untreated hyperthyroidism, age ranging between 20 and 50 years, were subjected to an oral glucose tolerance test with 100 g glucose. The serum thyroxine, triiodothyronine, reverse triiodothyronine, and TSH concentrations remained unchanged. This ruled out the possibility that modifications of thyroid hormone secretion or of thyroid hormone metabolism in response to acute glucose loading might affect the secretion of insulin and C peptide. It has been confirmed by the results that the insulin response to oral glucose loading, in proportion to the increase in blood glucose concentration, is weaker in hyperthyroid than in euthyroid subjects, At the same time, extraction of insulin in the liver is slightly increased in thyrotoxicosis. All this may contribute to the impaired glucose tolerance associated with hyperthyroidism. The results also indicate that the insulin response to oral glucose loading in hyperthyroidism remains unaffected by the administration of beta-blocking agents.

UR - http://www.scopus.com/inward/record.url?scp=0019720344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019720344&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0019720344

VL - 38

SP - 197

EP - 205

JO - Acta Medica Academiae Scientiarum Hungaricae

JF - Acta Medica Academiae Scientiarum Hungaricae

SN - 0001-5989

IS - 3

ER -