Secretion and breakdown of insulin in hyperthyroidism

J. Foldes, C. Banos, A. Varadi

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Abstract

In a study of the disorders of glucose metabolism associated with hyperthyroidism 16 euthyroid subjects and 19 patients with untreated hyperthyroidism, age ranging between 20 and 50 years, were subjected to an oral glucose tolerance test with 100 g glucose. The serum thyroxine, triiodothyronine, reverse triiodothyronine, and TSH concentrations remained unchanged. This ruled out the possibility that modifications of thyroid hormone secretion or of thyroid hormone metabolism in response to acute glucose loading might affect the secretion of insulin and C peptide. It has been confirmed by the results that the insulin response to oral glucose loading, in proportion to the increase in blood glucose concentration, is weaker in hyperthyroid than in euthyroid subjects, At the same time, extraction of insulin in the liver is slightly increased in thyrotoxicosis. All this may contribute to the impaired glucose tolerance associated with hyperthyroidism. The results also indicate that the insulin response to oral glucose loading in hyperthyroidism remains unaffected by the administration of beta-blocking agents.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalActa medica Academiae Scientiarum Hungaricae
Volume38
Issue number3
Publication statusPublished - Jan 1 1981

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ASJC Scopus subject areas

  • Medicine(all)

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