Secretin and autism

A basic morphological study about the distribution of secretin in the nervous system

K. Köves, Mária Kausz, Diana Reser, G. Illyés, J. Takács, Andrea Heinzlmann, Eszter Gyenge, Károly Horváth

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

For the first time, the relationship between secretin and autism has been demonstrated by one of us. Intravenous administration of secretin in autistic children caused a fivefold higher pancreaticobiliary fluid secretion than in healthy ones and, at least in some of the patients, better mental functions were reported after the secretin test. Because the precise localization of secretin in the brain is still not completely known, the abovementioned observation led us to map secretin immunoreactivity in the nervous system of several mammalian species. In the present work, the distribution of secretin immunoreactivity in cat and human nervous systems was compared with that of rats using an immunohistochemical approach. Secretin immunoreactivity was observed in the following brain structures of both humans and in colchicine-treated rats: (1) Purkinje cells in the cerebellar cortex; (2) central cerebellar nuclei; (3) pyramidal cells in the motor cortex; and (4) primary sensory neurons. Additionally, secretin immnoreactive cells were observed in the human hippocampus and amygdala and in third-order sensory neurons of the rat auditory system. In cats, secretin was only observed in the spinal ganglia. Our findings support the view that secretin is not only a gastrointestinal peptide but that it is also a neuropeptide. Its presence or the lack of its presence may have a role in the development of behavioral disorders.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalRegulatory Peptides
Volume123
Issue number1-3 SPEC. ISS.
DOIs
Publication statusPublished - Dec 15 2004

Fingerprint

Secretin
Neurology
Autistic Disorder
Nervous System
Rats
Sensory Receptor Cells
Neurons
Brain
Cats
Fluids and Secretions
Cerebellar Nuclei
Cerebellar Cortex
Pyramidal Cells
Purkinje Cells
Mentally Ill Persons
Colchicine
Motor Cortex
Spinal Ganglia
Amygdala
Neuropeptides

Keywords

  • Cat
  • Human
  • Immunohistochemistry
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Secretin and autism : A basic morphological study about the distribution of secretin in the nervous system. / Köves, K.; Kausz, Mária; Reser, Diana; Illyés, G.; Takács, J.; Heinzlmann, Andrea; Gyenge, Eszter; Horváth, Károly.

In: Regulatory Peptides, Vol. 123, No. 1-3 SPEC. ISS., 15.12.2004, p. 209-216.

Research output: Contribution to journalArticle

Köves, K. ; Kausz, Mária ; Reser, Diana ; Illyés, G. ; Takács, J. ; Heinzlmann, Andrea ; Gyenge, Eszter ; Horváth, Károly. / Secretin and autism : A basic morphological study about the distribution of secretin in the nervous system. In: Regulatory Peptides. 2004 ; Vol. 123, No. 1-3 SPEC. ISS. pp. 209-216.
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