Secondary metabolites from the leaves of Digitalis viridiflora

Hasan Kirmizibekmez, Norbert Kúsz, Nursenem Karaca, Fatih Demirci, Judit Hohmann

Research output: Contribution to journalArticle

1 Citation (Scopus)


A new phenylethanoid glycoside, named digiviridifloroside (1), was isolated from the leaves of Digitalis viridiflora Lindley along with a known phenylethanoid glycoside, calceolarioside A (2), two flavonoid glycosides, scutellarein 7-O-β-D-glucopyranoside (3) and hispidulin 7-O-β-D-glucopyranoside (4), two cleroindicins, cleroindicins B (5) and F (6), a nucleoside, adenosine (7), as well as a mixture of β-glucopyranosyl-(1→6)-4-O-caffeoyl-/β-glucopyranose and 3,4-dihydroxyphenylethanol. The structure of the new compound was established as 3,4-dihydroxy-β-phenylethoxy-6-O-(E)-feruloyl-β-glucopyranosyl-(1→6)-4-O-(E)-caffeoyl-β-glucopyranoside (1) based on extensive 1D-and 2D-NMR spectroscopy, as well as HR-ESI-MS. Digiviridifloroside represents a rare type of phenylethanoid glycoside which bears two aromatic acyl units in its structure. In addition to phytochemical studies, the isolates were evaluated for their in vitro antimicrobial activities against three pathogenic bacteria and three yeast strains using a microdilution method. Among the tested compounds, 5 exhibited moderate antibacterial activity against Bacillus cereus NRRLB 3711 with a MIC value of 25 μg/mL, whereas compounds 5 and 6 showed relatively high anticandidal activity against Candida strains with MIC values down to 12.5 μg/mL, in comparison to the standard antimicrobial compounds.

Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalNatural product communications
Issue number1
Publication statusPublished - Jan 1 2017


  • Antimicrobial activity
  • Digitalis viridiflora
  • Digiviridifloroside
  • Phenylethanoid glycoside
  • Plantaginaceae

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Fingerprint Dive into the research topics of 'Secondary metabolites from the leaves of Digitalis viridiflora'. Together they form a unique fingerprint.

  • Cite this