Secondary metabolites from the endophytic fungus Pestalotiopsis virgatula isolated from the mangrove plant Sonneratia caseolaris

David Rönsberg, Abdessamad Debbab, Attila Mándi, Victor Wray, Haofu Dai, Tibor Kurtán, Peter Proksch, Amal H. Aly

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Chromatographic analysis of an ethyl acetate extract of Pestalotiopsis virgatula rice cultures yielded four new α-pyrone derivatives, pestalotiopyrones I-L, and the new (6S,1′S,2′S)-hydroxypestalotin, in addition to three known compounds. The planar structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. The absolute configurations of the new compounds were determined on the basis of biosynthetic considerations, coupling constants, and for pestalotiopyrone L by TDDFT ECD calculations of solution conformers.

Original languageEnglish
Pages (from-to)3256-3259
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number25
DOIs
Publication statusPublished - Jun 19 2013

Keywords

  • Endophytic fungi
  • Pestalotiopsis virgatula
  • Sonneratia caseolaris
  • α-Pyrones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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