Bórinfiltrációval járó B-sejtes krónikus lymphoid leukaemia.

Translated title of the contribution: Secondary cutaneous infiltration in B-cell chronic lymphocytic leukemia (B-CLL)

J. Várkonyi, A. Zalatnai, J. Tímár, A. Matolcsi, E. Pócsik, B. Kotlán, A. Császár, V. László, M. Bencsáth, A. Falus

Research output: Contribution to journalArticle

Abstract

Authors report here on a case presenting as B-CLL and complicated with cutaneous infiltration involving the legs and the trunk a year later. Immunohistochemic analysis and the immunoglobulin heavy chain gene rearrangement confirmed cell invasion into the skin identical with the underlying disorder. After failure of conventional chemotherapy, interferon alpha 2b therapy has been started with satisfactory result. Few cases presenting cutaneous infiltration in the course of B-CLL has already been reported in the literature. Secondary cutaneous B-cell lymphoma represents an entity of the poorest prognosis in comparison with primary cutaneous form treated with conventional therapy as well as with lymphomas lacking skin manifestations. Interferon alpha 2b therapy cleans up the skin and yields a favourable survival so it's introduction recommended in this entity. Authors summarise the characteristics of secondary cutaneous B-cell lymphomas on the basis of literature survey. According to authors investigations histidine decarboxylase activity was found to be absent from the lymphocytes infiltrating the skin in contrast to those remaining in the circulation. This seems to be a newly recognised feature of these cells. The changing character of the disease raises the possibility of an altered gene expression pattern of the cells invading the skin. Authors summarise data from the literature concerning suspected molecular mechanism of tissue invasion.

Original languageHungarian
Pages (from-to)1297-1300
Number of pages4
JournalOrvosi Hetilap
Volume141
Issue number23
Publication statusPublished - Jun 4 2000

Fingerprint

B-Cell Chronic Lymphocytic Leukemia
Skin
interferon alfa-2b
B-Cell Lymphoma
Histidine Decarboxylase
Immunoglobulin Heavy Chain Genes
Skin Manifestations
Gene Rearrangement
Lymphoma
Leg
Therapeutics
Lymphocytes
Gene Expression
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bórinfiltrációval járó B-sejtes krónikus lymphoid leukaemia. / Várkonyi, J.; Zalatnai, A.; Tímár, J.; Matolcsi, A.; Pócsik, E.; Kotlán, B.; Császár, A.; László, V.; Bencsáth, M.; Falus, A.

In: Orvosi Hetilap, Vol. 141, No. 23, 04.06.2000, p. 1297-1300.

Research output: Contribution to journalArticle

@article{9775b403b7294becad432bb83fbf797b,
title = "B{\'o}rinfiltr{\'a}ci{\'o}val j{\'a}r{\'o} B-sejtes kr{\'o}nikus lymphoid leukaemia.",
abstract = "Authors report here on a case presenting as B-CLL and complicated with cutaneous infiltration involving the legs and the trunk a year later. Immunohistochemic analysis and the immunoglobulin heavy chain gene rearrangement confirmed cell invasion into the skin identical with the underlying disorder. After failure of conventional chemotherapy, interferon alpha 2b therapy has been started with satisfactory result. Few cases presenting cutaneous infiltration in the course of B-CLL has already been reported in the literature. Secondary cutaneous B-cell lymphoma represents an entity of the poorest prognosis in comparison with primary cutaneous form treated with conventional therapy as well as with lymphomas lacking skin manifestations. Interferon alpha 2b therapy cleans up the skin and yields a favourable survival so it's introduction recommended in this entity. Authors summarise the characteristics of secondary cutaneous B-cell lymphomas on the basis of literature survey. According to authors investigations histidine decarboxylase activity was found to be absent from the lymphocytes infiltrating the skin in contrast to those remaining in the circulation. This seems to be a newly recognised feature of these cells. The changing character of the disease raises the possibility of an altered gene expression pattern of the cells invading the skin. Authors summarise data from the literature concerning suspected molecular mechanism of tissue invasion.",
author = "J. V{\'a}rkonyi and A. Zalatnai and J. T{\'i}m{\'a}r and A. Matolcsi and E. P{\'o}csik and B. Kotl{\'a}n and A. Cs{\'a}sz{\'a}r and V. L{\'a}szl{\'o} and M. Bencs{\'a}th and A. Falus",
year = "2000",
month = "6",
day = "4",
language = "Hungarian",
volume = "141",
pages = "1297--1300",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "23",

}

TY - JOUR

T1 - Bórinfiltrációval járó B-sejtes krónikus lymphoid leukaemia.

AU - Várkonyi, J.

AU - Zalatnai, A.

AU - Tímár, J.

AU - Matolcsi, A.

AU - Pócsik, E.

AU - Kotlán, B.

AU - Császár, A.

AU - László, V.

AU - Bencsáth, M.

AU - Falus, A.

PY - 2000/6/4

Y1 - 2000/6/4

N2 - Authors report here on a case presenting as B-CLL and complicated with cutaneous infiltration involving the legs and the trunk a year later. Immunohistochemic analysis and the immunoglobulin heavy chain gene rearrangement confirmed cell invasion into the skin identical with the underlying disorder. After failure of conventional chemotherapy, interferon alpha 2b therapy has been started with satisfactory result. Few cases presenting cutaneous infiltration in the course of B-CLL has already been reported in the literature. Secondary cutaneous B-cell lymphoma represents an entity of the poorest prognosis in comparison with primary cutaneous form treated with conventional therapy as well as with lymphomas lacking skin manifestations. Interferon alpha 2b therapy cleans up the skin and yields a favourable survival so it's introduction recommended in this entity. Authors summarise the characteristics of secondary cutaneous B-cell lymphomas on the basis of literature survey. According to authors investigations histidine decarboxylase activity was found to be absent from the lymphocytes infiltrating the skin in contrast to those remaining in the circulation. This seems to be a newly recognised feature of these cells. The changing character of the disease raises the possibility of an altered gene expression pattern of the cells invading the skin. Authors summarise data from the literature concerning suspected molecular mechanism of tissue invasion.

AB - Authors report here on a case presenting as B-CLL and complicated with cutaneous infiltration involving the legs and the trunk a year later. Immunohistochemic analysis and the immunoglobulin heavy chain gene rearrangement confirmed cell invasion into the skin identical with the underlying disorder. After failure of conventional chemotherapy, interferon alpha 2b therapy has been started with satisfactory result. Few cases presenting cutaneous infiltration in the course of B-CLL has already been reported in the literature. Secondary cutaneous B-cell lymphoma represents an entity of the poorest prognosis in comparison with primary cutaneous form treated with conventional therapy as well as with lymphomas lacking skin manifestations. Interferon alpha 2b therapy cleans up the skin and yields a favourable survival so it's introduction recommended in this entity. Authors summarise the characteristics of secondary cutaneous B-cell lymphomas on the basis of literature survey. According to authors investigations histidine decarboxylase activity was found to be absent from the lymphocytes infiltrating the skin in contrast to those remaining in the circulation. This seems to be a newly recognised feature of these cells. The changing character of the disease raises the possibility of an altered gene expression pattern of the cells invading the skin. Authors summarise data from the literature concerning suspected molecular mechanism of tissue invasion.

UR - http://www.scopus.com/inward/record.url?scp=0034604187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034604187&partnerID=8YFLogxK

M3 - Article

VL - 141

SP - 1297

EP - 1300

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 23

ER -