"Sebocytes' makeup" - Novel mechanisms and concepts in the physiology of the human sebaceous glands

Balázs I. Tóth, Attila Oláh, Attila G. Szöllosi, Gabriella Czifra, Tamás Bíró

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

The pilosebaceous unit of the human skin consists of the hair follicle and the sebaceous gland. Within this "mini-organ", the sebaceous gland has been neglected by the researchers of the field for several decades. Actually, it was labeled as a reminiscence of human development ("a living fossil with a past but no future"), and was thought to solely act as a producer of sebum, a lipid-enriched oily substance which protects our skin (and hence the body) against various insults. However, due to emerging research activities of the past two decades, it has now become evident that the sebaceous gland is not only a "passive" cutaneous "relic" to establish the physico-chemical barrier function of the skin against constant environmental challenges, but it rather functions as an "active" neuro-immuno-endocrine cutaneous organ. This review summarizes recent findings of sebaceous gland research by mainly focusing on newly discovered physiological functions, novel regulatory mechanisms, key events in the pathology of the gland, and future directions in both experimental and clinical dermatology.

Original languageEnglish
Pages (from-to)593-606
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Volume461
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • Acne vulgaris
  • Human sebaceous gland
  • Immuno-endocrine functions
  • Lipid synthesis
  • Signal transduction

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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