Sebocytes differentially express and secrete adipokines

Dóra Kovács, Marianna Lovászi, Szilárd Póliska, Attila Oláh, T. Bíró, Imre Veres, Christos C. Zouboulis, Mona Ståhle, Ralph Rühl, E. Remenyik, D. Törőcsik

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In addition to producing sebum, sebocytes link lipid metabolism with inflammation at a cellular level and hence, greatly resemble adipocytes. However, so far no analysis was performed to identify and characterize the adipocyte-associated inflammatory proteins, the members of the adipokine family in sebocytes. Therefore, we determined the expression profile of adipokines [adiponectin, interleukin (IL) 6, resistin, leptin, serpin E1, visfatin, apelin, chemerin, retinol-binding protein 4 (RBP4) and monocyte chemoattractant protein 1 (MCP1)] in sebaceous glands of healthy and various disease-affected (acne, rosacea, melanoma and psoriasis) skin samples. Sebaceous glands in all examined samples expressed adiponectin, IL6, resistin, leptin, serpin E1 and visfatin, but not apelin, chemerin, RBP4 and MCP1. Confirming the presence of the detected adipokines in the human SZ95 sebaceous gland cell line we further characterized their expression and secretion patterns under different stimuli mimicking bacterial invasion [by using Toll-like receptor (TLR)2 and 4 activators], or by 13-cis retinoic acid (13CRA; also known as isotretinoin), a key anti-acne agent. With the exception of resistin, the expression of all of the detected adipokines (adiponectin, IL6, leptin, serpin E1 and visfatin) could be further regulated at the level of gene expression, showing a close correlation with the secreted protein levels. Besides providing further evidence on similarities between adipocytes and sebocytes, our results strongly suggest that sebocytes are not simply targets of inflammation but may exhibit initiatory and modulatory roles in the inflammatory processes of the skin through the expression and secretion of adipokines.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalExperimental Dermatology
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Adipokines
Nicotinamide Phosphoribosyltransferase
Resistin
Sebaceous Glands
Adiponectin
Plasminogen Activator Inhibitor 1
Leptin
Adipocytes
Retinol-Binding Proteins
Interleukin-6
Isotretinoin
Chemokine CCL2
Skin
Sebum
Inflammation
Rosacea
Toll-Like Receptor 2
Toll-Like Receptor 4
Acne Vulgaris
Lipid Metabolism

Keywords

  • Adipokine
  • Inflammation
  • Sebocyte

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

Cite this

Sebocytes differentially express and secrete adipokines. / Kovács, Dóra; Lovászi, Marianna; Póliska, Szilárd; Oláh, Attila; Bíró, T.; Veres, Imre; Zouboulis, Christos C.; Ståhle, Mona; Rühl, Ralph; Remenyik, E.; Törőcsik, D.

In: Experimental Dermatology, Vol. 25, No. 3, 01.03.2016, p. 194-199.

Research output: Contribution to journalArticle

Kovács, D, Lovászi, M, Póliska, S, Oláh, A, Bíró, T, Veres, I, Zouboulis, CC, Ståhle, M, Rühl, R, Remenyik, E & Törőcsik, D 2016, 'Sebocytes differentially express and secrete adipokines', Experimental Dermatology, vol. 25, no. 3, pp. 194-199. https://doi.org/10.1111/exd.12879
Kovács D, Lovászi M, Póliska S, Oláh A, Bíró T, Veres I et al. Sebocytes differentially express and secrete adipokines. Experimental Dermatology. 2016 Mar 1;25(3):194-199. https://doi.org/10.1111/exd.12879
Kovács, Dóra ; Lovászi, Marianna ; Póliska, Szilárd ; Oláh, Attila ; Bíró, T. ; Veres, Imre ; Zouboulis, Christos C. ; Ståhle, Mona ; Rühl, Ralph ; Remenyik, E. ; Törőcsik, D. / Sebocytes differentially express and secrete adipokines. In: Experimental Dermatology. 2016 ; Vol. 25, No. 3. pp. 194-199.
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