Search for the optimal monosodium glutamate treatment schedule to study the neuroprotective effects of PACAP in the retina

Norbert Babai, Tamas Atlasz, A. Tamás, D. Reglodi, G. Tóth, P. Kiss, R. Gábriel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have previously shown the protective effects of pituitary adenylate cyclaseactivating polypeptide (PACAP) in monosodium glutamate (MSG)-induced retinal degeneration. In the present article, we have investigated the optimal model for examining this neuroprotective effect. One MSG treatment on postnatal (P) days 1 or 5, in spite of leading to same ultrastructural changes, does not cause enough damage to study neuroprotection. When retinas were treated three times with MSG, the entire inner retina degenerated. Neuroprotection with PACAP was achieved with at least two treatments. Evidence suggests that PACAP provides protection against excitotoxicity, therefore, it may be a useful agent in reducing excitotoxic damage in the retina.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1070
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Sodium Glutamate
Neuroprotective Agents
Retina
Appointments and Schedules
Peptides
Retinal Degeneration
Reducing Agents
Neuroprotection
Damage

Keywords

  • Degeneration
  • MSG
  • PACAP
  • Plexiform layers
  • Retina
  • Ribbon synapses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "We have previously shown the protective effects of pituitary adenylate cyclaseactivating polypeptide (PACAP) in monosodium glutamate (MSG)-induced retinal degeneration. In the present article, we have investigated the optimal model for examining this neuroprotective effect. One MSG treatment on postnatal (P) days 1 or 5, in spite of leading to same ultrastructural changes, does not cause enough damage to study neuroprotection. When retinas were treated three times with MSG, the entire inner retina degenerated. Neuroprotection with PACAP was achieved with at least two treatments. Evidence suggests that PACAP provides protection against excitotoxicity, therefore, it may be a useful agent in reducing excitotoxic damage in the retina.",
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AU - Babai, Norbert

AU - Atlasz, Tamas

AU - Tamás, A.

AU - Reglodi, D.

AU - Tóth, G.

AU - Kiss, P.

AU - Gábriel, R.

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AB - We have previously shown the protective effects of pituitary adenylate cyclaseactivating polypeptide (PACAP) in monosodium glutamate (MSG)-induced retinal degeneration. In the present article, we have investigated the optimal model for examining this neuroprotective effect. One MSG treatment on postnatal (P) days 1 or 5, in spite of leading to same ultrastructural changes, does not cause enough damage to study neuroprotection. When retinas were treated three times with MSG, the entire inner retina degenerated. Neuroprotection with PACAP was achieved with at least two treatments. Evidence suggests that PACAP provides protection against excitotoxicity, therefore, it may be a useful agent in reducing excitotoxic damage in the retina.

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