Screening of isolates from faeces for carbapenem-resistant Bacteroides strains; existence of strains with novel types of resistance mechanisms

J. Sóki, Richard Edwards, E. Urbán, Eleonóra Fodor, Zsuzsanna Beer, E. Nagy

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Isolates from faecal samples (n = 224) from the UK and Hungary were screened for carbapenem-resistant Bacteroides strains and were consecutively investigated for the resistance mechanisms through detection of cfiA genes, the presence or lack of insertion sequence insertions in their upstream regions and the production of carbapenemase activities. In this way, a significant number of strains (n = 7, 3.1%) were recovered. They included 2 Bacteroides fragilis strains (one in each country) which harboured cfiA genes, but which were not activated by insertion sequence elements; this is reminiscent of some novel clinical B. fragilis strains. The cfiA-negative strains exhibited lower levels of carbapenem resistance and varying levels of carbapenemase activity, suggesting that other resistance mechanisms may also exist.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number5
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Bacteroides fragilis
Bacteroides
Carbapenems
Feces
DNA Transposable Elements
Hungary
Insertional Mutagenesis
Genes
carbapenemase

Keywords

  • Bacteroides
  • Carbapenemase
  • cfiA
  • Faeces

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Screening of isolates from faeces for carbapenem-resistant Bacteroides strains; existence of strains with novel types of resistance mechanisms. / Sóki, J.; Edwards, Richard; Urbán, E.; Fodor, Eleonóra; Beer, Zsuzsanna; Nagy, E.

In: International Journal of Antimicrobial Agents, Vol. 24, No. 5, 11.2004, p. 450-454.

Research output: Contribution to journalArticle

@article{1760dd602c2e436d821713e696a39cdc,
title = "Screening of isolates from faeces for carbapenem-resistant Bacteroides strains; existence of strains with novel types of resistance mechanisms",
abstract = "Isolates from faecal samples (n = 224) from the UK and Hungary were screened for carbapenem-resistant Bacteroides strains and were consecutively investigated for the resistance mechanisms through detection of cfiA genes, the presence or lack of insertion sequence insertions in their upstream regions and the production of carbapenemase activities. In this way, a significant number of strains (n = 7, 3.1{\%}) were recovered. They included 2 Bacteroides fragilis strains (one in each country) which harboured cfiA genes, but which were not activated by insertion sequence elements; this is reminiscent of some novel clinical B. fragilis strains. The cfiA-negative strains exhibited lower levels of carbapenem resistance and varying levels of carbapenemase activity, suggesting that other resistance mechanisms may also exist.",
keywords = "Bacteroides, Carbapenemase, cfiA, Faeces",
author = "J. S{\'o}ki and Richard Edwards and E. Urb{\'a}n and Eleon{\'o}ra Fodor and Zsuzsanna Beer and E. Nagy",
year = "2004",
month = "11",
doi = "10.1016/j.ijantimicag.2004.06.017",
language = "English",
volume = "24",
pages = "450--454",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Screening of isolates from faeces for carbapenem-resistant Bacteroides strains; existence of strains with novel types of resistance mechanisms

AU - Sóki, J.

AU - Edwards, Richard

AU - Urbán, E.

AU - Fodor, Eleonóra

AU - Beer, Zsuzsanna

AU - Nagy, E.

PY - 2004/11

Y1 - 2004/11

N2 - Isolates from faecal samples (n = 224) from the UK and Hungary were screened for carbapenem-resistant Bacteroides strains and were consecutively investigated for the resistance mechanisms through detection of cfiA genes, the presence or lack of insertion sequence insertions in their upstream regions and the production of carbapenemase activities. In this way, a significant number of strains (n = 7, 3.1%) were recovered. They included 2 Bacteroides fragilis strains (one in each country) which harboured cfiA genes, but which were not activated by insertion sequence elements; this is reminiscent of some novel clinical B. fragilis strains. The cfiA-negative strains exhibited lower levels of carbapenem resistance and varying levels of carbapenemase activity, suggesting that other resistance mechanisms may also exist.

AB - Isolates from faecal samples (n = 224) from the UK and Hungary were screened for carbapenem-resistant Bacteroides strains and were consecutively investigated for the resistance mechanisms through detection of cfiA genes, the presence or lack of insertion sequence insertions in their upstream regions and the production of carbapenemase activities. In this way, a significant number of strains (n = 7, 3.1%) were recovered. They included 2 Bacteroides fragilis strains (one in each country) which harboured cfiA genes, but which were not activated by insertion sequence elements; this is reminiscent of some novel clinical B. fragilis strains. The cfiA-negative strains exhibited lower levels of carbapenem resistance and varying levels of carbapenemase activity, suggesting that other resistance mechanisms may also exist.

KW - Bacteroides

KW - Carbapenemase

KW - cfiA

KW - Faeces

UR - http://www.scopus.com/inward/record.url?scp=7044235809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044235809&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2004.06.017

DO - 10.1016/j.ijantimicag.2004.06.017

M3 - Article

VL - 24

SP - 450

EP - 454

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 5

ER -