Screening detected celiac disease in children with type 1 diabetes mellitus: Effect on the clinical course (a case control study)

Birgit Rami, Zdenek Sumnik, Edith Schober, Thomas Waldhör, Tadej Battelino, Nina Bratanic, Kalman Kürti, Jan Lebl, Catarina Limbert, L. Madácsy, Roetloef J H Odink, Magdalena Paskova, G. Soltész

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Abstract

Objective: To investigate clinical and metabolic characteristics of diabetic children with screening detected celiac disease in a multicenter case-control study. Methods: Cases: 98 diabetic patients were diagnosed as having silent celiac disease by screening with endomysial antibodies and subsequent biopsy. Controls: two controls in the same center were chosen, (stratified by age and age-at-diabetes onset) who were negative for endomysial antibodies (n = 195). Height, weight, HbAlc, insulin dosage and acute complications were documented for at least 1 year of follow up. Results: Mean age of diabetes manifestation was 6.5 ± 4.1 years and diagnosis of celiac disease was made at 10.0 ± 5.4 years. Biopsy showed total or subtotal mucosal atrophy in 74 patients. The mean observation period after the diagnosis of celiac disease was 3.3 ± 1.9 years. Mean HbAlc levels were similar between cases and controls (8.63% ± 1.45% versus 8.50% ± 1.39%; P = 0.35). There was also no difference in the frequency of severe hypoglycemia, ketoacidosis and the applied insulin dosage (P = 0.45). Body mass index-standard deviation score at celiac disease diagnosis (0.57 ± 1.24 versus 0.52 ± 1.07) and height-standard deviation score (0.14 ± 1.13 versus 0.30 ± 0.95) did not differ between cases and controls. After diagnosis of celiac disease, weight gain was diminished in boys with celiac disease compared with their controls (P <0.05). Female cases also had a lower body mass index than female controls (P = 0.067). Conclusion: In a cohort of diabetic children, silent celiac disease had no obvious effect on metabolic control but negatively influenced weight gain.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume41
Issue number3
DOIs
Publication statusPublished - Sep 2005

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celiac disease
insulin-dependent diabetes mellitus
Celiac Disease
case-control studies
Type 1 Diabetes Mellitus
disease course
Case-Control Studies
screening
Weight Gain
body mass index
diabetes
biopsy
Body Mass Index
insulin
weight gain
Insulin
Biopsy
Ketosis
ketosis
antibodies

Keywords

  • Celiac disease
  • Children
  • Diabetes mellitus
  • Follow up

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Screening detected celiac disease in children with type 1 diabetes mellitus : Effect on the clinical course (a case control study). / Rami, Birgit; Sumnik, Zdenek; Schober, Edith; Waldhör, Thomas; Battelino, Tadej; Bratanic, Nina; Kürti, Kalman; Lebl, Jan; Limbert, Catarina; Madácsy, L.; Odink, Roetloef J H; Paskova, Magdalena; Soltész, G.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 41, No. 3, 09.2005, p. 317-321.

Research output: Contribution to journalArticle

Rami, Birgit ; Sumnik, Zdenek ; Schober, Edith ; Waldhör, Thomas ; Battelino, Tadej ; Bratanic, Nina ; Kürti, Kalman ; Lebl, Jan ; Limbert, Catarina ; Madácsy, L. ; Odink, Roetloef J H ; Paskova, Magdalena ; Soltész, G. / Screening detected celiac disease in children with type 1 diabetes mellitus : Effect on the clinical course (a case control study). In: Journal of Pediatric Gastroenterology and Nutrition. 2005 ; Vol. 41, No. 3. pp. 317-321.
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