Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

Andrea Czompa, Balázs László Pásztor, Jennifer Alizadeh Sahar, Zoltán Mucsi, Dóra Bogdán, K. Ludányi, Zoltán Varga, I. Mándity

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Original languageEnglish
Pages (from-to)37818-37824
Number of pages7
JournalRSC Advances
Volume9
Issue number65
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction'. Together they form a unique fingerprint.

  • Cite this