Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier

Malcolm V. Pimm, Alan C. Perkins, Ference Hudecz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

There is a growing interest in the use of macromolecular carriers for therapeutic agents. If these carriers can be labelled with an appropriate gamma-emitter, their biodistribution could be followed by scintigraphy. We have imaged the biodistribution of a synthetic branched polypeptide, based on a poly-L-lysine backbone (average molecular mass 45 kDa). The polymer was conjugated to diethylene triamine penta-acetic acid and labelled by chelation with indium-111. Mice were injected i.v. with labelled material and imaged with a gamma-camera with a pin-hole collimator. Images showed the majority of tracer remaining in the blood pool, but about 35% appeared in the urinary bladder within 1.5 h. When the 111In-polymer was fractionated by gel filtration chromatography on S-300, the imaging showed that the early eluting material was retained, the intermediate showed some renal clearance, and the late was rapidly excreted. These findings show the value of gamma-scintigraphy for biodistribution studies with such polymeric drug carriers and its potential for clinical pharmacokinetic studies.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalEuropean Journal of Nuclear Medicine
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 1 1992

Keywords

  • Biodistribution
  • Polymers
  • Scintigraphy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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