Schizophrenia: Redox regulation and volume neurotransmission

I. Bókkon, I. Antal

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Here, we show that volume neurotransmission and the redox property of dopamine, as well as redox-regulated processes at glutamate receptors, can contribute significantly to our understanding of schizophrenia. Namely, volume neurotransmission may play a key role in the development of dysconnectivity between brain regions in schizophrenic patients, which can cause abnormal modulation of NMDA-dependent synaptic plasticity and produce local paroxysms in deafferented neural areas. During synaptic transmission, neuroredox regulations have fundamental functions, which involve the excellent antioxidant properties and nonsynaptic neurotransmission of dopamine. It is possible that the effect of redox-linked volume neurotransmission(diffusion) of dopamine is not as exact as communication by the classical synaptic mechanism, sp approaching the study of complex schizophrenic mechanisms from this perspective may be benificial. However, knowledge of redox signal processes, including the sources and molecular targets of reactive species, is essential for understanding the physiological and pathophysiological signal pathways in cells and the brain, as well as for pharmacological design of various types of new drugs.

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalCurrent Neuropharmacology
Volume9
Issue number2
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Synaptic Transmission
Oxidation-Reduction
Schizophrenia
Dopamine
Neuronal Plasticity
Glutamate Receptors
Brain
N-Methylaspartate
Signal Transduction
Antioxidants
Communication
Pharmacology
Pharmaceutical Preparations

Keywords

  • Dopamine
  • Glutamate receptors
  • Redox regulations
  • Volume neurotransmission

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

Schizophrenia : Redox regulation and volume neurotransmission. / Bókkon, I.; Antal, I.

In: Current Neuropharmacology, Vol. 9, No. 2, 06.2011, p. 289-300.

Research output: Contribution to journalArticle

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