Szkizofrénia, környezet és epigenetika

Translated title of the contribution: Schizophrenia, environment and epigenetics

Must Anita, Janka Zoltán, Horváth Szatmár

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20% of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce socalled epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.

Translated title of the contributionSchizophrenia, environment and epigenetics
Original languageHungarian
Pages (from-to)211-217
Number of pages7
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number4
DOIs
Publication statusPublished - Dec 1 2011

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

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