Szkizofrénia, környezet és epigenetika

Translated title of the contribution: Schizophrenia, environment and epigenetics

Must Anita, Z. Janka, Horváth Szatmár

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20% of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce socalled epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.

Original languageHungarian
Pages (from-to)211-217
Number of pages7
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number4
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Epigenomics
Schizophrenia
Research
Neurobehavioral Manifestations
Affective Symptoms
Disease Susceptibility
Genetic Predisposition to Disease
Mental Disorders
Gene Expression
Population
Genes
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Szkizofrénia, környezet és epigenetika. / Anita, Must; Janka, Z.; Szatmár, Horváth.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 4, 12.2011, p. 211-217.

Research output: Contribution to journalArticle

Anita, Must ; Janka, Z. ; Szatmár, Horváth. / Szkizofrénia, környezet és epigenetika. In: Neuropsychopharmacologia Hungarica. 2011 ; Vol. 13, No. 4. pp. 211-217.
@article{fa686ad3a2d94c4da61ad0953c2e93d3,
title = "Szkizofr{\'e}nia, k{\"o}rnyezet {\'e}s epigenetika",
abstract = "Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20{\%} of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce socalled epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.",
keywords = "Environmental factors, Epigenetics, Schizophrenia, Vulnerability",
author = "Must Anita and Z. Janka and Horv{\'a}th Szatm{\'a}r",
year = "2011",
month = "12",
doi = "10.5706/nph201112004",
language = "Hungarian",
volume = "13",
pages = "211--217",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "4",

}

TY - JOUR

T1 - Szkizofrénia, környezet és epigenetika

AU - Anita, Must

AU - Janka, Z.

AU - Szatmár, Horváth

PY - 2011/12

Y1 - 2011/12

N2 - Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20% of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce socalled epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.

AB - Psychotic, cognitive and affective symptoms defining schizophrenia may, though much less severe, manifest themselves in up to 10 to 20% of the general population. What explains the fact that in certain cases the symptoms require even constant medical supervision, while others are capable of living a normal life within social conventions? Which factors lead to the transition of mild, subclinical manifestations and vulnerability indicators towards the outburst of one of the most severe and depriving mental disorders? Genetic susceptibility is undoubtedly crucial. More recent research findings emphasize the modifying effect of specific environmental factors on gene expression. The gene-environment interplay may induce socalled epigenetic alterations which may manifest themselves over several generations. Future integrative, multi-dimensional and flexible schizophrenia research approaches focusing on the identification of neurobiological and cognitive outcomes are much needed to understand disease vulnerability, susceptibility mechanisms, periods and interactions. Research methods may differ, but our aim is common - establishing more effective diagnostic and therapeutic interventions.

KW - Environmental factors

KW - Epigenetics

KW - Schizophrenia

KW - Vulnerability

UR - http://www.scopus.com/inward/record.url?scp=84858243359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858243359&partnerID=8YFLogxK

U2 - 10.5706/nph201112004

DO - 10.5706/nph201112004

M3 - Article

VL - 13

SP - 211

EP - 217

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 4

ER -