Scavenger effect of experimental and clinically used cardiovascular drugs

Zsolt Marton, Robert Halmosi, Beata Horvath, Tamas Alexy, Gabor Kesmarky, Judit Vekasi, Istvan Battyany, Kalman Hideg, Kalman Toth

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Oxygen free radicals play an important role in several physiologic and pathophysiologic processes. In pathophysiologic circumstances they can modify and damage biologic systems. Their functional properties (exposed to high oxygen tension) place red blood cells among the most susceptible cells to the harmful effect of free radicals. Because oxygen free radicals are involved in a wide range of diseases, scavenging these radicals should be an important therapeutic approach. In this study the antioxidant capacities of experimental and clinically used cardiovascular drugs were investigated. Phenazine methosulfate was used to generate free radicals and thus harden red blood cells. Filtration technique and potassium leaking were used to detect the scavenging effect of the examined drugs. The experimental drug H-2545 provided 43% protection against phenazine methosulfate-induced changes in red blood cell filterability (p < 0.001). Although some of the examined, clinically used cardiovascular drugs (carvedilol, metoprolol, verapamil, trimetazidine) also showed significant (p < 0.05) antioxidant effect, they were less efficient than H-2545. The scavenger effect of this novel drug exceeded the antioxidant properties of vitamin E. Modification of mexiletine with a pyrroline ring significantly improved its antioxidant capacity, suggesting that this molecular segment is responsible for the antioxidant effect.

Original languageEnglish
Pages (from-to)745-753
Number of pages9
JournalJournal of cardiovascular pharmacology
Volume38
Issue number5
DOIs
Publication statusPublished - Oct 31 2001

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Keywords

  • Antioxidant
  • Cardiovascular
  • Oxygen free radical
  • Red blood cell filtration

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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