Scaffolds are 'active' regulators of signaling modules

Anita Alexa, János Varga, Attila Reményi

Research output: Contribution to journalShort survey

11 Citations (Scopus)

Abstract

Signaling cascades, in addition to proteins with obvious signaling-relevant activities (e.g. protein kinases or receptors), also employ dedicated 'inactive' proteins whose functions appear to be the organization of the former components into higher order complexes through protein-protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex. Several recent studies have demonstrated that the recruiter and the recruited molecules mutually influence each other in a scaffolded complex. This yields fundamentally novel properties for the signaling complex as a whole. Because these are not merely additive to the properties of the individual components, scaffolded signaling complexes may behave as functionally distinct modules.

Original languageEnglish
Pages (from-to)4376-4382
Number of pages7
JournalFEBS Journal
Volume277
Issue number21
DOIs
Publication statusPublished - Nov 1 2010

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Keywords

  • Cellular signaling
  • InaD
  • KSR1
  • MAPK module
  • PSD95
  • Phosphorylation of scaffold
  • Protein kinase
  • Signaling cascade
  • Signaling scaffold
  • Ste5

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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