TELITETT HETEROCIKLUSOK, 216. TRANSZ-PERHIDRO-1,4-BENZOXAZEPIN-3-ON SZARMAZEKOK SZINTEZISE ES GYURUFELNYILASA

Translated title of the contribution: Saturated heterocycles. Part 216. Synthesis, structure and ring opening of trans-perhydro-1,4-benzoxazepin-3-one derivatives

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Abstract

Trans-perhydro-1,4-benzoxazepin-3-ones 2a-e were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b, the thiones 4a,b, the urea derivatives 5a,b, and N-acylated compounds 6a-e. Compounds 6b,d were ring-opened by hydrochloride acid in ethanol to yield trans-2-(1-carbethoxyethoxy)-1-(acylaminomethyl)-cyclohexane derivatives 7b,d. The 1H- and 13C-nmr investigation and X-ray analysis of 5b and 6c,d proved that the expected N-acylated derivatives were formed and that both rings of the annelated compounds have a chair conformation.

Original languageHungarian
Pages (from-to)111-118
Number of pages8
JournalActa pharmaceutica Hungarica
Volume66
Issue number3
Publication statusPublished - Jun 18 1996

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ASJC Scopus subject areas

  • Pharmaceutical Science

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