Saturated heterocycles, Part 172. Synthesis of 2,6‐disubstituted‐5,6,7,8‐tetrahydropyrido[4,3‐d]pyrimidine derivatives

János Lázár, Gábor Bernáth

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The title compounds were synthesized via the addition of methyl acrylate to benzylamine or to α‐aminopyridine, which gave the corresponding diesters, e.g. 12, followed by Dieckmann condensation of the latter to yield the keto‐esters 13, which were condensed with amidines and guanidines, 3, 14. Removal of the benzyl group by hydrogenolysis and subsequent alkylation of the nitrogen atom at position 6 in the resulting compound 5, with variation of the substituents on C‐2, gave a number of products with potential biological action; some of them gave analgesic and anti‐inflammatory effects.

Original languageEnglish
Pages (from-to)1885-1892
Number of pages8
JournalJournal of Heterocyclic Chemistry
Volume27
Issue number7
DOIs
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Organic Chemistry

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