Saturated Heterocycles. 242 [1]. Synthesis of 2-Substituted-6-(6′,7′-dimethoxy-3′,4′-dihydro-1′- isoquinolyl)-5,6,7,8-tetrahydro-quinazolin-4(3H)-one Derivatives

Gábor Bernáth, Jeno Kóbor, János Lázár, Ferenc Fülöp

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In the reactions of the recently synthesized β-ketoesters 1-[(3′-methoxycarbonyl- and 1-[(3′-ethoxycar-bonyl-4′-oxo)-1′-cyclohexyl]-3,4- dihydroisoquinoline 4,5 with amidines or cyclic guanidines, a number of 2-substituted-6-(6′,7′-dimethoxy-3′,4′-dihydro-1′- isoquinolyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one derivatives 6-8 were prepared. The new compounds possess various pharmacological actions.

Original languageEnglish
Pages (from-to)1983-1987
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number6
Publication statusPublished - Jan 1 1996


ASJC Scopus subject areas

  • Organic Chemistry

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