Satietin: A highly potent anorexogenic substance in human serum

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was discovered in human serum. The substance was extracted and purified by gelchromatographic techniques. The purified satietin containing samples exerted a dose-dependent anorexogenic effect both at intravenous and intracerebroventricular injection. The C-terminal octapeptide of cholecystokinin (CCK-OP) and pGlu-His-GlyOH, the peptides described to reduce food intake in nonstarving rodents, were found to be devoid of satietin-like effect in rats deprived of food for 4 days.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalPhysiology and Behavior
Volume23
Issue number3
DOIs
Publication statusPublished - 1979

Fingerprint

Sincalide
Eating
Serum
Food
Intravenous Injections
Rodentia
Peptides
satietin
pyroglutamylhistidine

Keywords

  • Amphetamine
  • Anorexogenic peptides
  • CCK-OP
  • Endogenous anorexogenic substance
  • Intracerebroventricular administration of anorexogenics
  • pGlu-His-GlyOH
  • Satietin
  • TRH

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Satietin : A highly potent anorexogenic substance in human serum. / Knoll, J.

In: Physiology and Behavior, Vol. 23, No. 3, 1979, p. 497-502.

Research output: Contribution to journalArticle

@article{4a7a5455dbd8473e90afd8f9632e874a,
title = "Satietin: A highly potent anorexogenic substance in human serum",
abstract = "A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was discovered in human serum. The substance was extracted and purified by gelchromatographic techniques. The purified satietin containing samples exerted a dose-dependent anorexogenic effect both at intravenous and intracerebroventricular injection. The C-terminal octapeptide of cholecystokinin (CCK-OP) and pGlu-His-GlyOH, the peptides described to reduce food intake in nonstarving rodents, were found to be devoid of satietin-like effect in rats deprived of food for 4 days.",
keywords = "Amphetamine, Anorexogenic peptides, CCK-OP, Endogenous anorexogenic substance, Intracerebroventricular administration of anorexogenics, pGlu-His-GlyOH, Satietin, TRH",
author = "J. Knoll",
year = "1979",
doi = "10.1016/0031-9384(79)90049-0",
language = "English",
volume = "23",
pages = "497--502",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Satietin

T2 - A highly potent anorexogenic substance in human serum

AU - Knoll, J.

PY - 1979

Y1 - 1979

N2 - A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was discovered in human serum. The substance was extracted and purified by gelchromatographic techniques. The purified satietin containing samples exerted a dose-dependent anorexogenic effect both at intravenous and intracerebroventricular injection. The C-terminal octapeptide of cholecystokinin (CCK-OP) and pGlu-His-GlyOH, the peptides described to reduce food intake in nonstarving rodents, were found to be devoid of satietin-like effect in rats deprived of food for 4 days.

AB - A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was discovered in human serum. The substance was extracted and purified by gelchromatographic techniques. The purified satietin containing samples exerted a dose-dependent anorexogenic effect both at intravenous and intracerebroventricular injection. The C-terminal octapeptide of cholecystokinin (CCK-OP) and pGlu-His-GlyOH, the peptides described to reduce food intake in nonstarving rodents, were found to be devoid of satietin-like effect in rats deprived of food for 4 days.

KW - Amphetamine

KW - Anorexogenic peptides

KW - CCK-OP

KW - Endogenous anorexogenic substance

KW - Intracerebroventricular administration of anorexogenics

KW - pGlu-His-GlyOH

KW - Satietin

KW - TRH

UR - http://www.scopus.com/inward/record.url?scp=0018731905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018731905&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(79)90049-0

DO - 10.1016/0031-9384(79)90049-0

M3 - Article

C2 - 116263

AN - SCOPUS:0018731905

VL - 23

SP - 497

EP - 502

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 3

ER -