Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats

Balázs Radnai, Zoltán Kandár, Anikó Somogyvári-Vigh, Z. Mergl, Márk Oláh, F. Fülöp, M. Vecsernyés, György M. Nagy

Research output: Contribution to journalArticle

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Abstract

Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the median eminence (ME), neuro-intermediate lobe (NIL) and the anterior lobe (AL) have been measured following 15-min of intravenous injection of salsolinol (SAL). Parallel to the elevation of plasma prolactin (PRL), SAL induced a significant decrease of cAMP concentration in the ME. In contrast, SAL injection resulted in a significant increase of cAMP at the level of the AL. Changes in cAMP of the NIL as well as in the plasma level of vasopressin (VP) could not be detected. The observed changes in the level of cAMP following the acute treatment of SAL in the ME and the AL seems to be related to interacting neuroendocrine signals delivered from the ME to the AL through the long portal vessels to release PRL.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalBrain Research Bulletin
Volume65
Issue number2
DOIs
Publication statusPublished - Mar 15 2005

Fingerprint

Median Eminence
Anterior Pituitary Gland
Cyclic AMP
Prolactin
Pituitary Gland
Vasopressins
Intravenous Injections
salsolinol
Injections

Keywords

  • Pituitary gland
  • Prolactin
  • Tetrahydroisoquinoline
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats. / Radnai, Balázs; Kandár, Zoltán; Somogyvári-Vigh, Anikó; Mergl, Z.; Oláh, Márk; Fülöp, F.; Vecsernyés, M.; Nagy, György M.

In: Brain Research Bulletin, Vol. 65, No. 2, 15.03.2005, p. 105-110.

Research output: Contribution to journalArticle

Radnai, Balázs ; Kandár, Zoltán ; Somogyvári-Vigh, Anikó ; Mergl, Z. ; Oláh, Márk ; Fülöp, F. ; Vecsernyés, M. ; Nagy, György M. / Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats. In: Brain Research Bulletin. 2005 ; Vol. 65, No. 2. pp. 105-110.
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AU - Mergl, Z.

AU - Oláh, Márk

AU - Fülöp, F.

AU - Vecsernyés, M.

AU - Nagy, György M.

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