Salivary genomics, transcriptomics and proteomics: The emerging concept of the oral ecosystem and their use in the early diagnosis of cancer and other diseases

T. K. Fábian, P. Fejérdy, P. Csermely

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

There is an increasingly growing interest world-wide for the genomics, transcriptomics and proteomics of saliva and the oral cavity, since they provide a non-invasive source of unprecedently rich genetic information. The complexity of oral systems biology goes much beyond the human genome, transcriptome and proteome revealed by oral mucosal cells, gingival crevicular fluid, and saliva, and includes the complexity of the oral microbiota, the symbiotic assembly of bacterial, fungal and other microbial flora in the oral cavity. In our review we summarize the recent information on oral genomics, transcriptomics and proteomics, of both human and microbial origin. We also give an introduction and practical advice on sample collection, handling and storage for analysis. Finally, we show the usefulness of salivary and oral genomics in early diagnosis of cancer, as well as in uncovering other systemic diseases, infections and oral disorders. We close the review by highlighting a number of possible exploratory pathways in this emerging, hot research field.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalCurrent Genomics
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 1 2008

    Fingerprint

Keywords

  • Early diagnosis
  • Genome
  • Oral diseases
  • Proteome
  • Saliva
  • Screening
  • Systemic diseases
  • Transcriptome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this