Salicylate reduces ventricular dysfunction and arrhythmias during reperfusion in isolated rat hearts

Xuekun Liu, A. Tósaki, Richard M. Engelman, Dipak K. Das

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH±) generated during reperfusion in ischemic myocardium. Since OH± is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. Isolated rat hearts perfused by the Langendorff technique were preperfused with Krebs-Henseleit buffer containing SA for 10 min. Hearts were then made ischemic for 30 min, followed by 30 min of reperfusion. In a separate group, SA was administered only at the onset of reperfusion. The left ventricular contractile functions, left ventricular developed pressure (LVDP) and its first derivative (LV dP/dt), coronary flow (CF), and creatine kinase (CK) release were determined before and after ischemia. Epicardial electrocardiogram (ECG) was also recorded to analyze the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF). SA improved LVDP, LV dp/dt, and CF recovery and reduced CK release compared to the control group. The incidence of VT and VF during reperfusion was also significantly reduced by SA. Analysis of tissue thiobarbituric acid-reactive products indicates that SA decreased oxidative stress during reperfusion. In conclusion, these results suggest that SA reduces myocardial reperfusion injury and attenuates ventricular arrhythmias by trapping OH± radicals upon reperfusion in isolated rat hearts.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume19
Issue number2
Publication statusPublished - 1992

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Ventricular Dysfunction
Salicylic Acid
Salicylates
Reperfusion
Cardiac Arrhythmias
Ventricular Fibrillation
Ventricular Pressure
Ventricular Tachycardia
Creatine Kinase
Myocardial Reperfusion Injury
Incidence
Reperfusion Injury
Left Ventricular Function
Hydroxyl Radical
Myocardium
Electrocardiography
Oxidative Stress
Ischemia
Control Groups

Keywords

  • Arrhythmias
  • Hydroxyl radical
  • Ischemia
  • Reperfusion injury
  • Salicylic acid
  • Ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Salicylate reduces ventricular dysfunction and arrhythmias during reperfusion in isolated rat hearts. / Liu, Xuekun; Tósaki, A.; Engelman, Richard M.; Das, Dipak K.

In: Journal of Cardiovascular Pharmacology, Vol. 19, No. 2, 1992, p. 209-215.

Research output: Contribution to journalArticle

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