Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties

Jessica Nilsson, Albert A. Shteinman, Eva Degerman, Eva A. Enyedy, Tamás Kiss, Ulrich Behrens, Dieter Rehder, Ebbe Nordlander

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H 2papy) with VOSO 4 in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)} 2 μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H 2glysal) with VOSO 4 gives [(glysal)VO(H 2O)] (2) and reaction of salicylamide (Hsalam) with VOSO 4 in methanol gives [(salam) 2VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.

Original languageEnglish
Pages (from-to)1795-1800
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume105
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Diabetes
  • Insulin mimicry
  • Vanadium

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties'. Together they form a unique fingerprint.

  • Cite this