Salicifoline and salicinolide, new diterpene polyesters from Euphorbia salicifolia

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Two new diterpenes (1 and 2) were isolated from a dichloromethane extract of fresh, whole plants of Euphorbia salicifolia: salicifoline (1) is the first representative of a new type of tricyclic diterpenes involving a novel 5-8-8 fused ring system, and salicinolide (2) is a bishomoditerpene lactone based on the jatrophane skeleton. The carbon skeleton of 1 is formally derived from jatrophane via transannular intramolecular C-C bond formation between C-12 and C-17.

Original languageEnglish
Pages (from-to)6581-6584
Number of pages4
JournalTetrahedron Letters
Issue number37
Publication statusPublished - Sep 10 2001


  • Diterpene polyester
  • Euphorbia salicifolia
  • Euphorbiaceae

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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