Safety and effectiveness of combined antihypertensive and cholesterol-lowering therapy in high-/very high-risk patients

Attila Kónyi, Zsolt Sárszegi, Gábor Hild, Balázs Gaszner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: Controlling cardiovascular (CV) risk factors is paramount in reducing atherosclerotic events. This 6-month prospective noninterventional trial assessed the safety and effectiveness of fixed-combination lisinopril-amlodipine plus rosuvastatin. Patients & methods: Patients with mild/moderate hypertension and hypercholesterolemia, at high-/very high-CV risk, received lisinopril-amlodipine (10/5, 20/5 or 20/10 mg/day) plus rosuvastatin (10 or 20 mg/day). Primary end points: systolic/diastolic blood pressure, low-density lipoprotein cholesterol. Results: At 6 months, 91% of 2241 evaluable patients achieved blood pressure target (<140/90 mmHg); low-density lipoprotein cholesterol targets, <3, <2.5 and 1.8 mmol/l, were achieved by 67, 49 and 40% of patients, respectively. Adverse events (4.4%) were mostly mild. Conclusion: Lisinopril-amlodipine plus rosuvastatin was well tolerated and effective in patients with mild/moderate hypertension and hypercholesterolemia at high/very high CV risk.

Original languageEnglish
Pages (from-to)355-364
Number of pages10
JournalJournal of Comparative Effectiveness Research
Volume5
Issue number4
DOIs
Publication statusPublished - Jul 2016

Keywords

  • cardiovascular risk
  • diabetes mellitus
  • hypercholesterolemia
  • hypertension
  • lisinopril-amlodipine
  • rosuvastatin

ASJC Scopus subject areas

  • Health Policy

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