Safening activity of natural hydroxamic acids and analogous compounds against herbicide injury to maize

István Jablonkai, Ferenc Dutka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Safening activities of natural compounds DIMBOA, DIBOA, and MBOA, as well as synthetic 1,4-benzoxazin-3-ones were tested against acetochlor and EPTC injuries to maize. No safening activities of natural products and from low to moderate activity of synthetic benzoxazinones were observed. In order to explain inefficacy of natural compounds we studied the influence of these molecules on enzymes participating in metabolic detoxication of acetochlor and EPTC. Pretreatment with DIMBOA elevated maize cytochrome P450 levels. Pretreatments with chemicals containing 1,4-benzoxazin-3-one backbone did not alter glutathione S-transferase enzyme activities. However, all natural products inhibited glutathione S-transferase activity of roots and shoots in vitro after addition to the enzyme. Safening ineffectiveness of natural hydroxamic acids may be explained by their inhibitory effects on GST enzymes due to their reaction with sulfhydryl groups on the enzyme.

Original languageEnglish
Pages (from-to)555-559
Number of pages5
JournalJournal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
Volume31
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

Keywords

  • 1,4-benzoxazin-3-one
  • DIBOA
  • DIMBOA
  • EPTC
  • MBOA
  • acetochlor
  • cytochrome P450
  • glutathione S- transferase

ASJC Scopus subject areas

  • Food Science
  • Pollution

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