S6K1 and E2FB are in mutually antagonistic regulatory links controlling cell growth and proliferation in Arabidopsis

Rossana Henriques, Z. Magyar, László Bögre

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Plant development is dependent on the coordination between growth and cell proliferation. The nutrient sensing TOR kinase and its downstream target, the 40S ribosomal S6 Kinase, are central controllers of cell growth that were also shown to determine cell size by inhibiting the onset of mitosis in yeast and animal cells. We have shown that the Arabidopsis S6 Kinase1 inhibits cell proliferation through the RBR-E2FB complex. S6K1 interacts with RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through E2FB. Here we show that S6K1 and E2FB are in a mutually antagonistic relationship both in their protein abundance and in their activity. We propose that this double inhibitory regulatory connection between S6K1 and E2FB forms a regulatory switch that might be important to determine whether cells divide or grow.

Original languageEnglish
JournalPlant Signaling and Behavior
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 2013

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cell growth
cell proliferation
Arabidopsis
phosphotransferases (kinases)
controllers
cells
mitosis
plant development
cell cycle
yeasts
nutrients
animals
genes
proteins

Keywords

  • Arabidopsis
  • Cell growth
  • Cell proliferation
  • E2FB
  • Protein stability
  • RBR
  • S6K1

ASJC Scopus subject areas

  • Plant Science

Cite this

S6K1 and E2FB are in mutually antagonistic regulatory links controlling cell growth and proliferation in Arabidopsis. / Henriques, Rossana; Magyar, Z.; Bögre, László.

In: Plant Signaling and Behavior, Vol. 8, No. 6, 06.2013.

Research output: Contribution to journalArticle

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