Ryanodine receptor channel-dependent glutathione transport in the sarcoplasmic reticulum of skeletal muscle

Miklós Csala, Rosella Fulceri, József Mandl, Angelo Benedetti, Gábor Bánhegyi

Research output: Contribution to journalArticle

11 Citations (Scopus)


We found that glutathione transport across endo/sarcoplasmic reticulum membranes correlates with the abundance of ryanodine receptor type 1 (RyR1). The transport was the fastest in muscle terminal cisternae, fast in muscle microsomes and slow in liver, heart, and brain microsomes. Glutathione influx could be inhibited by RyR1 blockers and the inhibitory effect was counteracted by RyR1 agonists. The effect of blockers was specific to glutathione, as the transport of other small molecules was not hindered. Therefore, the glutathione transport activity seems to be associated with RyR1 in sarcoplasmic reticulum.

Original languageEnglish
Pages (from-to)696-700
Number of pages5
JournalBiochemical and biophysical research communications
Issue number3
Publication statusPublished - Sep 28 2001


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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