Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

Marie Louise Lehmann, Silvia Selinski, Meinolf Blaszkewicz, Michael Orlich, Daniel Ovsiannikov, Oliver Moormann, Christoph Guballa, Alexander Kress, Michael C. Truss, Holger Gerullis, Thomas Otto, Dimitri Barski, Günter Niegisch, Peter Albers, Sebastian Frees, Walburgis Brenner, Joachim W. Thüroff, Miriam Angeli-Greaves, Thilo Seidel, Gerhard RothHolger Dietrich, Rainer Ebbinghaus, Hans M. Prager, Hermann M. Bolt, Michael Falkenstein, Anna Zimmermann, Torsten Klein, Thomas Reckwitz, Hermann C. Roemer, Dietrich Löhlein, Wobbeke Weistenhöfer, Wolfgang Schöps, Anwer E. Beg, Muhammad Aslam, Gergely Bánfi, I. Romics, Katja Ickstadt, Holger Schwender, Andreas Winterpacht, Jan G. Hengstler, Klaus Golka

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associatedwith increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by newdata and bymeta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95%Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P\0.0001). However, the odds ratio is relatively small.

Original languageEnglish
Pages (from-to)967-978
Number of pages12
JournalArchives of Toxicology
Volume84
Issue number12
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Chromosomes
Urinary Bladder Neoplasms
Association reactions
Meta-Analysis
Polymerase chain reaction
Polymorphism
Carcinogens
Venezuela
Hungary
Pakistan
Blood
Substitution reactions
Nucleotides
Individuality
Habits
Single Nucleotide Polymorphism
Germany
Real-Time Polymerase Chain Reaction
Urinary Bladder
Smoking

Keywords

  • Genetic variant
  • Genome-wide association study
  • Haploblock
  • Occupational exposure
  • Prevention
  • Rs710521[A]
  • Susceptibility
  • Tumour protein p63
  • Urothelial cancer

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Lehmann, M. L., Selinski, S., Blaszkewicz, M., Orlich, M., Ovsiannikov, D., Moormann, O., ... Golka, K. (2010). Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. Archives of Toxicology, 84(12), 967-978. https://doi.org/10.1007/s00204-010-0617-6

Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. / Lehmann, Marie Louise; Selinski, Silvia; Blaszkewicz, Meinolf; Orlich, Michael; Ovsiannikov, Daniel; Moormann, Oliver; Guballa, Christoph; Kress, Alexander; Truss, Michael C.; Gerullis, Holger; Otto, Thomas; Barski, Dimitri; Niegisch, Günter; Albers, Peter; Frees, Sebastian; Brenner, Walburgis; Thüroff, Joachim W.; Angeli-Greaves, Miriam; Seidel, Thilo; Roth, Gerhard; Dietrich, Holger; Ebbinghaus, Rainer; Prager, Hans M.; Bolt, Hermann M.; Falkenstein, Michael; Zimmermann, Anna; Klein, Torsten; Reckwitz, Thomas; Roemer, Hermann C.; Löhlein, Dietrich; Weistenhöfer, Wobbeke; Schöps, Wolfgang; Beg, Anwer E.; Aslam, Muhammad; Bánfi, Gergely; Romics, I.; Ickstadt, Katja; Schwender, Holger; Winterpacht, Andreas; Hengstler, Jan G.; Golka, Klaus.

In: Archives of Toxicology, Vol. 84, No. 12, 12.2010, p. 967-978.

Research output: Contribution to journalArticle

Lehmann, ML, Selinski, S, Blaszkewicz, M, Orlich, M, Ovsiannikov, D, Moormann, O, Guballa, C, Kress, A, Truss, MC, Gerullis, H, Otto, T, Barski, D, Niegisch, G, Albers, P, Frees, S, Brenner, W, Thüroff, JW, Angeli-Greaves, M, Seidel, T, Roth, G, Dietrich, H, Ebbinghaus, R, Prager, HM, Bolt, HM, Falkenstein, M, Zimmermann, A, Klein, T, Reckwitz, T, Roemer, HC, Löhlein, D, Weistenhöfer, W, Schöps, W, Beg, AE, Aslam, M, Bánfi, G, Romics, I, Ickstadt, K, Schwender, H, Winterpacht, A, Hengstler, JG & Golka, K 2010, 'Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk', Archives of Toxicology, vol. 84, no. 12, pp. 967-978. https://doi.org/10.1007/s00204-010-0617-6
Lehmann ML, Selinski S, Blaszkewicz M, Orlich M, Ovsiannikov D, Moormann O et al. Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. Archives of Toxicology. 2010 Dec;84(12):967-978. https://doi.org/10.1007/s00204-010-0617-6
Lehmann, Marie Louise ; Selinski, Silvia ; Blaszkewicz, Meinolf ; Orlich, Michael ; Ovsiannikov, Daniel ; Moormann, Oliver ; Guballa, Christoph ; Kress, Alexander ; Truss, Michael C. ; Gerullis, Holger ; Otto, Thomas ; Barski, Dimitri ; Niegisch, Günter ; Albers, Peter ; Frees, Sebastian ; Brenner, Walburgis ; Thüroff, Joachim W. ; Angeli-Greaves, Miriam ; Seidel, Thilo ; Roth, Gerhard ; Dietrich, Holger ; Ebbinghaus, Rainer ; Prager, Hans M. ; Bolt, Hermann M. ; Falkenstein, Michael ; Zimmermann, Anna ; Klein, Torsten ; Reckwitz, Thomas ; Roemer, Hermann C. ; Löhlein, Dietrich ; Weistenhöfer, Wobbeke ; Schöps, Wolfgang ; Beg, Anwer E. ; Aslam, Muhammad ; Bánfi, Gergely ; Romics, I. ; Ickstadt, Katja ; Schwender, Holger ; Winterpacht, Andreas ; Hengstler, Jan G. ; Golka, Klaus. / Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. In: Archives of Toxicology. 2010 ; Vol. 84, No. 12. pp. 967-978.
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abstract = "Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associatedwith increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by newdata and bymeta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95{\%} Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95{\%}Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95{\%} Cl = 1.12-1.25; P\0.0001). However, the odds ratio is relatively small.",
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T1 - Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

AU - Lehmann, Marie Louise

AU - Selinski, Silvia

AU - Blaszkewicz, Meinolf

AU - Orlich, Michael

AU - Ovsiannikov, Daniel

AU - Moormann, Oliver

AU - Guballa, Christoph

AU - Kress, Alexander

AU - Truss, Michael C.

AU - Gerullis, Holger

AU - Otto, Thomas

AU - Barski, Dimitri

AU - Niegisch, Günter

AU - Albers, Peter

AU - Frees, Sebastian

AU - Brenner, Walburgis

AU - Thüroff, Joachim W.

AU - Angeli-Greaves, Miriam

AU - Seidel, Thilo

AU - Roth, Gerhard

AU - Dietrich, Holger

AU - Ebbinghaus, Rainer

AU - Prager, Hans M.

AU - Bolt, Hermann M.

AU - Falkenstein, Michael

AU - Zimmermann, Anna

AU - Klein, Torsten

AU - Reckwitz, Thomas

AU - Roemer, Hermann C.

AU - Löhlein, Dietrich

AU - Weistenhöfer, Wobbeke

AU - Schöps, Wolfgang

AU - Beg, Anwer E.

AU - Aslam, Muhammad

AU - Bánfi, Gergely

AU - Romics, I.

AU - Ickstadt, Katja

AU - Schwender, Holger

AU - Winterpacht, Andreas

AU - Hengstler, Jan G.

AU - Golka, Klaus

PY - 2010/12

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N2 - Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associatedwith increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by newdata and bymeta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95%Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P\0.0001). However, the odds ratio is relatively small.

AB - Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associatedwith increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by newdata and bymeta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95%Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P\0.0001). However, the odds ratio is relatively small.

KW - Genetic variant

KW - Genome-wide association study

KW - Haploblock

KW - Occupational exposure

KW - Prevention

KW - Rs710521[A]

KW - Susceptibility

KW - Tumour protein p63

KW - Urothelial cancer

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