Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk

Silvia Selinski, Marie Louise Lehmann, Meinolf Blaszkewicz, Daniel Ovsiannikov, Oliver Moormann, Christoph Guballa, Alexander Kress, Michael C. Truß, Holger Gerullis, Thomas Otto, Dimitri Barski, Günter Niegisch, Peter Albers, Sebastian Frees, Walburgis Brenner, Joachim W. Thüroff, Miriam Angeli-Greaves, Thilo Seidel, Gerhard Roth, Frank VolkertRainer Ebbinghaus, Hans M. Prager, Hermann M. Bolt, Michael Falkenstein, Anna Zimmermann, Torsten Klein, Thomas Reckwitz, Hermann C. Roemer, Mark Hartel, Wobbeke Weistenhöfer, Wolfgang Schöps, S. Adibul Hassan Rizvi, Muhammad Aslam, Gergely Bánfi, I. Romics, Katja Ickstadt, Jan G. Hengstler, Klaus Golka

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Recently, rs11892031[A] has been identified in a genome-wide association study (GWAS) to confer increased risk of urinary bladder cancer (UBC). To confirm this association and additionally study a possible relevance of exposure to urinary bladder carcinogens, we investigated the IfADo UBC study group, consisting of eight case-control series from different regions including 1,805 cases and 2,141 controls. This analysis was supplemented by a meta-analysis of all published data, including 13,395 cases and 54,876 controls. Rs11892031 A/A was significantly associated with UBC risk in the IfADocase-control series adjusted to cigarette smoking, gender, age and ethnicity (OR = 1.18; 95% CI = 1.02-1.37; P = 0.026). In the meta-analysis, a convincing association with UBC risk was obtained (OR = 1.19; 95% Cl = 1.12-1.26; P <0.0001). Interestingly, the highest odds ratios were obtained for individual case-control series with a high degree of occupational exposure to polycyclic aromatic hydrocarbons and aromatic amines: cases with suspected occupational UBC (OR = 1.41) and cases from the highly industrialized Ruhr area (OR = 1.98) compared with Ruhr area controls (all combined OR = 1.46). Odds ratios were lower for study groups with no or a lower degree of occupational exposure to bladder carcinogens, such as the Hungary (OR = 1.02) or the ongoing West German case-control series (OR = 1.06). However, the possible association of rs11892031[A] with exposure to bladder carcinogens still should be interpreted with caution, because in contrast to the diVerences between the individual study groups, interview- based data on occupational exposure were not significantly associated with rs11892031. In conclusion, the association of rs11892031[A] with UBC risk could be confirmed in independent study groups.

Original languageEnglish
Pages (from-to)1369-1378
Number of pages10
JournalArchives of Toxicology
Volume86
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Chromosomes
Urinary Bladder Neoplasms
Occupational Exposure
Carcinogens
Urinary Bladder
Meta-Analysis
Odds Ratio
Hungary
Genome-Wide Association Study
Polycyclic Aromatic Hydrocarbons
Amines
Tobacco Products
Smoking
Interviews
Genes

Keywords

  • Aromatic amines
  • Benzidine
  • Polycyclic aromatic hydrocarbons (PAH)
  • rs17863783
  • Single nucleotide polymorphism (SNP)
  • UDP-glucuronosyltransferase 1A

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Selinski, S., Lehmann, M. L., Blaszkewicz, M., Ovsiannikov, D., Moormann, O., Guballa, C., ... Golka, K. (2012). Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. Archives of Toxicology, 86(9), 1369-1378. https://doi.org/10.1007/s00204-012-0854-y

Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. / Selinski, Silvia; Lehmann, Marie Louise; Blaszkewicz, Meinolf; Ovsiannikov, Daniel; Moormann, Oliver; Guballa, Christoph; Kress, Alexander; Truß, Michael C.; Gerullis, Holger; Otto, Thomas; Barski, Dimitri; Niegisch, Günter; Albers, Peter; Frees, Sebastian; Brenner, Walburgis; Thüroff, Joachim W.; Angeli-Greaves, Miriam; Seidel, Thilo; Roth, Gerhard; Volkert, Frank; Ebbinghaus, Rainer; Prager, Hans M.; Bolt, Hermann M.; Falkenstein, Michael; Zimmermann, Anna; Klein, Torsten; Reckwitz, Thomas; Roemer, Hermann C.; Hartel, Mark; Weistenhöfer, Wobbeke; Schöps, Wolfgang; Rizvi, S. Adibul Hassan; Aslam, Muhammad; Bánfi, Gergely; Romics, I.; Ickstadt, Katja; Hengstler, Jan G.; Golka, Klaus.

In: Archives of Toxicology, Vol. 86, No. 9, 09.2012, p. 1369-1378.

Research output: Contribution to journalArticle

Selinski, S, Lehmann, ML, Blaszkewicz, M, Ovsiannikov, D, Moormann, O, Guballa, C, Kress, A, Truß, MC, Gerullis, H, Otto, T, Barski, D, Niegisch, G, Albers, P, Frees, S, Brenner, W, Thüroff, JW, Angeli-Greaves, M, Seidel, T, Roth, G, Volkert, F, Ebbinghaus, R, Prager, HM, Bolt, HM, Falkenstein, M, Zimmermann, A, Klein, T, Reckwitz, T, Roemer, HC, Hartel, M, Weistenhöfer, W, Schöps, W, Rizvi, SAH, Aslam, M, Bánfi, G, Romics, I, Ickstadt, K, Hengstler, JG & Golka, K 2012, 'Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk', Archives of Toxicology, vol. 86, no. 9, pp. 1369-1378. https://doi.org/10.1007/s00204-012-0854-y
Selinski, Silvia ; Lehmann, Marie Louise ; Blaszkewicz, Meinolf ; Ovsiannikov, Daniel ; Moormann, Oliver ; Guballa, Christoph ; Kress, Alexander ; Truß, Michael C. ; Gerullis, Holger ; Otto, Thomas ; Barski, Dimitri ; Niegisch, Günter ; Albers, Peter ; Frees, Sebastian ; Brenner, Walburgis ; Thüroff, Joachim W. ; Angeli-Greaves, Miriam ; Seidel, Thilo ; Roth, Gerhard ; Volkert, Frank ; Ebbinghaus, Rainer ; Prager, Hans M. ; Bolt, Hermann M. ; Falkenstein, Michael ; Zimmermann, Anna ; Klein, Torsten ; Reckwitz, Thomas ; Roemer, Hermann C. ; Hartel, Mark ; Weistenhöfer, Wobbeke ; Schöps, Wolfgang ; Rizvi, S. Adibul Hassan ; Aslam, Muhammad ; Bánfi, Gergely ; Romics, I. ; Ickstadt, Katja ; Hengstler, Jan G. ; Golka, Klaus. / Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk. In: Archives of Toxicology. 2012 ; Vol. 86, No. 9. pp. 1369-1378.
@article{9a8a7f602f7245069c2cfe8e39d919b4,
title = "Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk",
abstract = "Recently, rs11892031[A] has been identified in a genome-wide association study (GWAS) to confer increased risk of urinary bladder cancer (UBC). To confirm this association and additionally study a possible relevance of exposure to urinary bladder carcinogens, we investigated the IfADo UBC study group, consisting of eight case-control series from different regions including 1,805 cases and 2,141 controls. This analysis was supplemented by a meta-analysis of all published data, including 13,395 cases and 54,876 controls. Rs11892031 A/A was significantly associated with UBC risk in the IfADocase-control series adjusted to cigarette smoking, gender, age and ethnicity (OR = 1.18; 95{\%} CI = 1.02-1.37; P = 0.026). In the meta-analysis, a convincing association with UBC risk was obtained (OR = 1.19; 95{\%} Cl = 1.12-1.26; P <0.0001). Interestingly, the highest odds ratios were obtained for individual case-control series with a high degree of occupational exposure to polycyclic aromatic hydrocarbons and aromatic amines: cases with suspected occupational UBC (OR = 1.41) and cases from the highly industrialized Ruhr area (OR = 1.98) compared with Ruhr area controls (all combined OR = 1.46). Odds ratios were lower for study groups with no or a lower degree of occupational exposure to bladder carcinogens, such as the Hungary (OR = 1.02) or the ongoing West German case-control series (OR = 1.06). However, the possible association of rs11892031[A] with exposure to bladder carcinogens still should be interpreted with caution, because in contrast to the diVerences between the individual study groups, interview- based data on occupational exposure were not significantly associated with rs11892031. In conclusion, the association of rs11892031[A] with UBC risk could be confirmed in independent study groups.",
keywords = "Aromatic amines, Benzidine, Polycyclic aromatic hydrocarbons (PAH), rs17863783, Single nucleotide polymorphism (SNP), UDP-glucuronosyltransferase 1A",
author = "Silvia Selinski and Lehmann, {Marie Louise} and Meinolf Blaszkewicz and Daniel Ovsiannikov and Oliver Moormann and Christoph Guballa and Alexander Kress and Tru{\ss}, {Michael C.} and Holger Gerullis and Thomas Otto and Dimitri Barski and G{\"u}nter Niegisch and Peter Albers and Sebastian Frees and Walburgis Brenner and Th{\"u}roff, {Joachim W.} and Miriam Angeli-Greaves and Thilo Seidel and Gerhard Roth and Frank Volkert and Rainer Ebbinghaus and Prager, {Hans M.} and Bolt, {Hermann M.} and Michael Falkenstein and Anna Zimmermann and Torsten Klein and Thomas Reckwitz and Roemer, {Hermann C.} and Mark Hartel and Wobbeke Weistenh{\"o}fer and Wolfgang Sch{\"o}ps and Rizvi, {S. Adibul Hassan} and Muhammad Aslam and Gergely B{\'a}nfi and I. Romics and Katja Ickstadt and Hengstler, {Jan G.} and Klaus Golka",
year = "2012",
month = "9",
doi = "10.1007/s00204-012-0854-y",
language = "English",
volume = "86",
pages = "1369--1378",
journal = "Archiv fur Toxikologie",
issn = "0003-9446",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk

AU - Selinski, Silvia

AU - Lehmann, Marie Louise

AU - Blaszkewicz, Meinolf

AU - Ovsiannikov, Daniel

AU - Moormann, Oliver

AU - Guballa, Christoph

AU - Kress, Alexander

AU - Truß, Michael C.

AU - Gerullis, Holger

AU - Otto, Thomas

AU - Barski, Dimitri

AU - Niegisch, Günter

AU - Albers, Peter

AU - Frees, Sebastian

AU - Brenner, Walburgis

AU - Thüroff, Joachim W.

AU - Angeli-Greaves, Miriam

AU - Seidel, Thilo

AU - Roth, Gerhard

AU - Volkert, Frank

AU - Ebbinghaus, Rainer

AU - Prager, Hans M.

AU - Bolt, Hermann M.

AU - Falkenstein, Michael

AU - Zimmermann, Anna

AU - Klein, Torsten

AU - Reckwitz, Thomas

AU - Roemer, Hermann C.

AU - Hartel, Mark

AU - Weistenhöfer, Wobbeke

AU - Schöps, Wolfgang

AU - Rizvi, S. Adibul Hassan

AU - Aslam, Muhammad

AU - Bánfi, Gergely

AU - Romics, I.

AU - Ickstadt, Katja

AU - Hengstler, Jan G.

AU - Golka, Klaus

PY - 2012/9

Y1 - 2012/9

N2 - Recently, rs11892031[A] has been identified in a genome-wide association study (GWAS) to confer increased risk of urinary bladder cancer (UBC). To confirm this association and additionally study a possible relevance of exposure to urinary bladder carcinogens, we investigated the IfADo UBC study group, consisting of eight case-control series from different regions including 1,805 cases and 2,141 controls. This analysis was supplemented by a meta-analysis of all published data, including 13,395 cases and 54,876 controls. Rs11892031 A/A was significantly associated with UBC risk in the IfADocase-control series adjusted to cigarette smoking, gender, age and ethnicity (OR = 1.18; 95% CI = 1.02-1.37; P = 0.026). In the meta-analysis, a convincing association with UBC risk was obtained (OR = 1.19; 95% Cl = 1.12-1.26; P <0.0001). Interestingly, the highest odds ratios were obtained for individual case-control series with a high degree of occupational exposure to polycyclic aromatic hydrocarbons and aromatic amines: cases with suspected occupational UBC (OR = 1.41) and cases from the highly industrialized Ruhr area (OR = 1.98) compared with Ruhr area controls (all combined OR = 1.46). Odds ratios were lower for study groups with no or a lower degree of occupational exposure to bladder carcinogens, such as the Hungary (OR = 1.02) or the ongoing West German case-control series (OR = 1.06). However, the possible association of rs11892031[A] with exposure to bladder carcinogens still should be interpreted with caution, because in contrast to the diVerences between the individual study groups, interview- based data on occupational exposure were not significantly associated with rs11892031. In conclusion, the association of rs11892031[A] with UBC risk could be confirmed in independent study groups.

AB - Recently, rs11892031[A] has been identified in a genome-wide association study (GWAS) to confer increased risk of urinary bladder cancer (UBC). To confirm this association and additionally study a possible relevance of exposure to urinary bladder carcinogens, we investigated the IfADo UBC study group, consisting of eight case-control series from different regions including 1,805 cases and 2,141 controls. This analysis was supplemented by a meta-analysis of all published data, including 13,395 cases and 54,876 controls. Rs11892031 A/A was significantly associated with UBC risk in the IfADocase-control series adjusted to cigarette smoking, gender, age and ethnicity (OR = 1.18; 95% CI = 1.02-1.37; P = 0.026). In the meta-analysis, a convincing association with UBC risk was obtained (OR = 1.19; 95% Cl = 1.12-1.26; P <0.0001). Interestingly, the highest odds ratios were obtained for individual case-control series with a high degree of occupational exposure to polycyclic aromatic hydrocarbons and aromatic amines: cases with suspected occupational UBC (OR = 1.41) and cases from the highly industrialized Ruhr area (OR = 1.98) compared with Ruhr area controls (all combined OR = 1.46). Odds ratios were lower for study groups with no or a lower degree of occupational exposure to bladder carcinogens, such as the Hungary (OR = 1.02) or the ongoing West German case-control series (OR = 1.06). However, the possible association of rs11892031[A] with exposure to bladder carcinogens still should be interpreted with caution, because in contrast to the diVerences between the individual study groups, interview- based data on occupational exposure were not significantly associated with rs11892031. In conclusion, the association of rs11892031[A] with UBC risk could be confirmed in independent study groups.

KW - Aromatic amines

KW - Benzidine

KW - Polycyclic aromatic hydrocarbons (PAH)

KW - rs17863783

KW - Single nucleotide polymorphism (SNP)

KW - UDP-glucuronosyltransferase 1A

UR - http://www.scopus.com/inward/record.url?scp=84866089139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866089139&partnerID=8YFLogxK

U2 - 10.1007/s00204-012-0854-y

DO - 10.1007/s00204-012-0854-y

M3 - Article

C2 - 22532026

AN - SCOPUS:84866089139

VL - 86

SP - 1369

EP - 1378

JO - Archiv fur Toxikologie

JF - Archiv fur Toxikologie

SN - 0003-9446

IS - 9

ER -