Rotavirus disease and vaccination: Impact on genotype diversity

Jelle Matthijnssens, Joke Bilcke, Max Ciarlet, Vito Martella, Krisztián Bányai, Mustafizur Rahman, Mark Zeller, Philippe Beutels, Pierre Van Damme, Marc Van Ranst

Research output: Contribution to journalReview article

214 Citations (Scopus)


Temporal and spatial fluctuations in the genotype distribution of human rotaviruses are continuously observed in surveillance studies. New genotypes, such as G9 and G12, have emerged and spread worldwide in a very short time span. In addition, reassortment events have the potential to contribute substantially to genetic diversity among human and animal rotaviruses. With the recent introduction of the two rotavirus vaccines, RotaTeq™ and Rotarix™, in many countries, it appears that the total number of hospitalizations due to rotavirus infections is being reduced, at least in developed countries that implemented a universal immunization program. However, continued surveillance is warranted, especially regarding the long-term effects of the vaccines. No data analyses are available to clarify whether rotavirus vaccine introduction would allow other rotavirus P and G genotypes, which are not covered by the current vaccines, to emerge into the human population and fill the apparent gap. This kind of data ana lysis is essential, but its interpretation is hampered by natural and cyclical genotype fluctuations.

Original languageEnglish
Pages (from-to)1303-1316
Number of pages14
JournalFuture Microbiology
Issue number10
Publication statusPublished - Dec 1 2009



  • Burden of disease
  • Epidemiology
  • Genetic diversity
  • Rotavirus
  • Vaccines

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Matthijnssens, J., Bilcke, J., Ciarlet, M., Martella, V., Bányai, K., Rahman, M., Zeller, M., Beutels, P., Van Damme, P., & Van Ranst, M. (2009). Rotavirus disease and vaccination: Impact on genotype diversity. Future Microbiology, 4(10), 1303-1316.