Roles of cortactin in tumor pathogenesis

L. Buday, Julian Downward

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for the protein kinase Src. It is accumulated in peripheral, actin-enriched structures of cells, including lamellipodia and membrane ruffles, suggesting that cortactin facilitates actin network formation. In addition, recent data suggests that it regulates various aspects of cell dynamics, including integrin signaling, vesicular transport, axon guidance, and cell migration. A large body of evidence indicates that cortactin is also implicated in the pathogenesis of human neoplasia. It is over-expressed in a number of epithelial carcinomas, including breast cancer and head and neck cancer. Over-expression of cortactin in human tumors has been proposed to result in increased cell migration and metastatic potential. This review aims to focus on cortactin-mediated signaling pathways, with emphasis on its contribution to tumor progression and metastasis formation.

Original languageEnglish
Pages (from-to)263-273
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1775
Issue number2
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Cortactin
Neoplasms
Head and Neck Neoplasms
Cell Movement
Actins
Microfilament Proteins
Pseudopodia
Integrins
Protein Kinases
Breast Neoplasms
Neoplasm Metastasis
Carcinoma
Membranes

Keywords

  • Cell migration
  • Cortactin
  • Invadopodium
  • Metastasis
  • Podosome
  • Tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Biophysics

Cite this

Roles of cortactin in tumor pathogenesis. / Buday, L.; Downward, Julian.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1775, No. 2, 06.2007, p. 263-273.

Research output: Contribution to journalArticle

Buday, L. ; Downward, Julian. / Roles of cortactin in tumor pathogenesis. In: Biochimica et Biophysica Acta - Reviews on Cancer. 2007 ; Vol. 1775, No. 2. pp. 263-273.
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