Role of tumour necrosis factor-α in insulin resistance during normal pregnancy

Zs Melczer, F. Bánhidy, S. Csömör, M. Kovács, P. Siklós, G. Winkler, K. Cseh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: Role of tumour necrosis factor-α (TNF-α) was studied in insulin resistance during pregnancy. Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study. Results: TNF-α (X±S.D.: 5.33±0.46pg/ml) and Cp levels (3.37±1.30ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07±0.26, Cp: 1.05±0.36) and to the pregnant women in 1st (TNF: 4.04±0.26, Cp: 1.34±0.59) and 2nd (TNF: 4.35±0.32, Cp: 1.11±0.35) trimesters. Significant positive linear correlation was calculated among TNF-α, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (P

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume105
Issue number1
DOIs
Publication statusPublished - Oct 10 2002

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C-Peptide
Insulin Resistance
Tumor Necrosis Factor-alpha
Pregnancy
Pregnant Women
Lymphotoxin-beta
Blood Glucose
Case-Control Studies
Fasting
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Serum

Keywords

  • Insulin resistance
  • Pregnancy
  • TNF-α

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Role of tumour necrosis factor-α in insulin resistance during normal pregnancy. / Melczer, Zs; Bánhidy, F.; Csömör, S.; Kovács, M.; Siklós, P.; Winkler, G.; Cseh, K.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 105, No. 1, 10.10.2002, p. 7-10.

Research output: Contribution to journalArticle

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