Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében

Translated title of the contribution: Role of tumour cell invasion/migration in the vascularisation of experimental lung metastases

Szabó Vanessza, Bugyik Edina, Dezsö Katalin, Tóvári József, B. Döme, Paku Sándor

Research output: Contribution to journalArticle

Abstract

Treatment of patients with lung metastases remains a major challenge. A possible target for therapies is the inhibition of vascularization of metastases. Our study aimed to determine the possible mechanisms of the experimental lung metastasis vascularisation for tumours of various origins. We created lung metastases by intravenous injection of five tumour cell lines (HT1080, HT25, B16, C26 and MATB). Each cell line showed the same vascularisation type. Tumours gained vasculature by advancing through the alveolar spaces thereby incorporating the pre-existing alveolar capillaries (i.e. vessel co-option). From the alveolar spaces tumours entered into the alveolar walls. The tumour cells during the invasion/migration separated the pneumocytes from the capillaries. During this process the basement membrane was split into an epithelial and an endothelial layer. The heavily compressed pneumocytes inside the tumour became fragmented but the incorporated and stripped vessels remained functional, so they were able to provide blood supply for the metastases.

Original languageHungarian
Pages (from-to)319-323
Number of pages5
JournalMagyar Onkologia
Volume59
Issue number4
Publication statusPublished - Jan 1 2015

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Cell Movement
Neoplasm Metastasis
Lung
Alveolar Epithelial Cells
Neoplasms
Tumor Cell Line
Basement Membrane
Intravenous Injections
Cell Line
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vanessza, S., Edina, B., Katalin, D., József, T., Döme, B., & Sándor, P. (2015). Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében. Magyar Onkologia, 59(4), 319-323.

Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében. / Vanessza, Szabó; Edina, Bugyik; Katalin, Dezsö; József, Tóvári; Döme, B.; Sándor, Paku.

In: Magyar Onkologia, Vol. 59, No. 4, 01.01.2015, p. 319-323.

Research output: Contribution to journalArticle

Vanessza, S, Edina, B, Katalin, D, József, T, Döme, B & Sándor, P 2015, 'Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében', Magyar Onkologia, vol. 59, no. 4, pp. 319-323.
Vanessza S, Edina B, Katalin D, József T, Döme B, Sándor P. Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében. Magyar Onkologia. 2015 Jan 1;59(4):319-323.
Vanessza, Szabó ; Edina, Bugyik ; Katalin, Dezsö ; József, Tóvári ; Döme, B. ; Sándor, Paku. / Tumorsejt-invázió/migráció szerepe kísérletes tüdömetasztázisok erezödésében. In: Magyar Onkologia. 2015 ; Vol. 59, No. 4. pp. 319-323.
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