Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases: Potential therapeutic targets?

Kata Csekő, Bram Beckers, Daniel Keszthelyi, Z. Helyes

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Inflammatory bowel diseases (IBD) have long been recognized to be accompanied by pain resulting in high morbidity. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. This review provides an overview of their expression and role in intestinal inflammation, in particular colitis, that appears to be virtually inconsistent based on the thorough investigations of the last twenty years. However, preclinical results with pharmacological interventions, as well as scarcely available human studies, more convincingly point out the potential therapeutic value of TRPV1 and TRPA1 antagonists in colitis and visceral hypersensitivity providing future therapeutical perspectives through a complex, unique mechanism of action for drug development in IBD.

Original languageEnglish
Article number48
JournalPharmaceuticals
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Ankyrins
Colitis
Ion Channels
Inflammatory Bowel Diseases
Neurogenic Inflammation
Capsaicin
Hyperalgesia
Sensory Receptor Cells
Hypersensitivity
Pharmacology
Inflammation
Morbidity
Pain
Therapeutics
Pharmaceutical Preparations
vanilloid receptor subtype 1

Keywords

  • Animal studies
  • Colitis models
  • Crohn’s disease
  • Human studies
  • IDB
  • TRPA1
  • TRPV1
  • Ulcerative colitis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases : Potential therapeutic targets? / Csekő, Kata; Beckers, Bram; Keszthelyi, Daniel; Helyes, Z.

In: Pharmaceuticals, Vol. 12, No. 2, 48, 01.06.2019.

Research output: Contribution to journalReview article

@article{7ad105794b3347ea830d050a00ebeaf4,
title = "Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases: Potential therapeutic targets?",
abstract = "Inflammatory bowel diseases (IBD) have long been recognized to be accompanied by pain resulting in high morbidity. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. This review provides an overview of their expression and role in intestinal inflammation, in particular colitis, that appears to be virtually inconsistent based on the thorough investigations of the last twenty years. However, preclinical results with pharmacological interventions, as well as scarcely available human studies, more convincingly point out the potential therapeutic value of TRPV1 and TRPA1 antagonists in colitis and visceral hypersensitivity providing future therapeutical perspectives through a complex, unique mechanism of action for drug development in IBD.",
keywords = "Animal studies, Colitis models, Crohn’s disease, Human studies, IDB, TRPA1, TRPV1, Ulcerative colitis",
author = "Kata Csekő and Bram Beckers and Daniel Keszthelyi and Z. Helyes",
year = "2019",
month = "6",
day = "1",
doi = "10.3390/ph12020048",
language = "English",
volume = "12",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Role of TRPV1 and TRPA1 ion channels in inflammatory bowel diseases

T2 - Potential therapeutic targets?

AU - Csekő, Kata

AU - Beckers, Bram

AU - Keszthelyi, Daniel

AU - Helyes, Z.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Inflammatory bowel diseases (IBD) have long been recognized to be accompanied by pain resulting in high morbidity. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. This review provides an overview of their expression and role in intestinal inflammation, in particular colitis, that appears to be virtually inconsistent based on the thorough investigations of the last twenty years. However, preclinical results with pharmacological interventions, as well as scarcely available human studies, more convincingly point out the potential therapeutic value of TRPV1 and TRPA1 antagonists in colitis and visceral hypersensitivity providing future therapeutical perspectives through a complex, unique mechanism of action for drug development in IBD.

AB - Inflammatory bowel diseases (IBD) have long been recognized to be accompanied by pain resulting in high morbidity. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. This review provides an overview of their expression and role in intestinal inflammation, in particular colitis, that appears to be virtually inconsistent based on the thorough investigations of the last twenty years. However, preclinical results with pharmacological interventions, as well as scarcely available human studies, more convincingly point out the potential therapeutic value of TRPV1 and TRPA1 antagonists in colitis and visceral hypersensitivity providing future therapeutical perspectives through a complex, unique mechanism of action for drug development in IBD.

KW - Animal studies

KW - Colitis models

KW - Crohn’s disease

KW - Human studies

KW - IDB

KW - TRPA1

KW - TRPV1

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=85068404701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068404701&partnerID=8YFLogxK

U2 - 10.3390/ph12020048

DO - 10.3390/ph12020048

M3 - Review article

AN - SCOPUS:85068404701

VL - 12

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 2

M1 - 48

ER -