Role of triglyceride modifier genetic variants in development of metabolic syndrome

A. Maász, P. Kisfali, Bela I. Melegh, Balazs Duga, Katalin Sümegi, B. Melegh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Metabolic syndrome is one of the most extensively studied conditions in all respects. According to the observation of hundreds of studies, metabolic syndrome represents global health problem. The prevalence of this condition shows huge differences in ethnic groups and it varies widely among children and adults, as well. Metabolic syndrome is a cluster of risk factors; the presence of which provides a predisposition to development of cardio- and cerebrovascular events. Thus, the importance of metabolic syndrome cannot be emphasized often enough. In the past decade, a vast number of association studies have been published, which have highlighted the role of genetic factors as possible risk factors in the development of metabolic syndrome. At first, classic susceptibility markers associated with other diseases were tested for their role in this condition. Subsequently, significant progression has been seen in the identification of functional genetic variants of the genes and genomic regions, including the triglyceride metabolism affecting loci. Nowadays, numerous susceptibility loci have been identified and the number of these variants exponentially increases due to the rapid spreading of genome wide association studies (GWAS). The goal of this chapter is to review the most recent information available on triglyceride metabolism influencing genetic variants that are also associated with development of metabolic syndrome.

Original languageEnglish
Title of host publicationHandbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact
PublisherNova Science Publishers, Inc.
Pages95-119
Number of pages25
ISBN (Print)9781622570256
Publication statusPublished - Nov 2012

Fingerprint

Triglycerides
Genome-Wide Association Study
Ethnic Groups
Observation
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maász, A., Kisfali, P., Melegh, B. I., Duga, B., Sümegi, K., & Melegh, B. (2012). Role of triglyceride modifier genetic variants in development of metabolic syndrome. In Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact (pp. 95-119). Nova Science Publishers, Inc..

Role of triglyceride modifier genetic variants in development of metabolic syndrome. / Maász, A.; Kisfali, P.; Melegh, Bela I.; Duga, Balazs; Sümegi, Katalin; Melegh, B.

Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact. Nova Science Publishers, Inc., 2012. p. 95-119.

Research output: Chapter in Book/Report/Conference proceedingChapter

Maász, A, Kisfali, P, Melegh, BI, Duga, B, Sümegi, K & Melegh, B 2012, Role of triglyceride modifier genetic variants in development of metabolic syndrome. in Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact. Nova Science Publishers, Inc., pp. 95-119.
Maász A, Kisfali P, Melegh BI, Duga B, Sümegi K, Melegh B. Role of triglyceride modifier genetic variants in development of metabolic syndrome. In Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact. Nova Science Publishers, Inc. 2012. p. 95-119
Maász, A. ; Kisfali, P. ; Melegh, Bela I. ; Duga, Balazs ; Sümegi, Katalin ; Melegh, B. / Role of triglyceride modifier genetic variants in development of metabolic syndrome. Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact. Nova Science Publishers, Inc., 2012. pp. 95-119
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